WormMine: AnatomyTerm WBbt:0006801

• Definition: neuron type, set of six neurons in the outer labial sensillum.
• Name: outer labial neuron
• Primary Identifier: WBbt:0006801
• Synonym: OL neuron

2 Children

Definition	Name	Synonym	Primary Identifier
Neuron class of four neurons with ciliated endings and striated rootlets in the dorsal and ventral outer labial sensilla.	OLQ		WBbt:0006848
Neuron class of two neurons with ciliated endings in the lateral outer labial sensilla.	OLL		WBbt:0006847

0 Expression Clusters

41 Expression Patterns

• Primary Identifier: Expr4591
• Pattern: The full-length dyf-5::gfp construct showed weak GFP expression in many neurons in the head, including amphid and labial sensory neurons and three pairs of neurons in the tail, including the phasmid sensory neurons. In addition, expression was observed in many cells in the male tail.
• Subcellular Localization: This DYF-5::GFP fusion could be detected uniformly in axons, cell bodies, and dendrites. In addition, authors observed strong fluorescence at the transition zones, which connect the cilia with the dendrites, and weak fluorescence uniformly in the cilia.

• Primary Identifier: Expr4592
• Pattern: The full-length dyf-5::gfp construct (see Expr4591) showed weak GFP expression in many neurons in the head, including amphid and labial sensory neurons and three pairs of neurons in the tail, including the phasmid sensory neurons. In addition, expression was observed in many cells in the male tail. The dyf-5ex4::gfp fusion construct essentially showed the same dyf-5 expression pattern, albeit stronger and more restricted to the cell bodies. In addition, DYF-5ex4::GFP could be detected in the CAN cells, neurons associated with the excretory canal and in a pair of neurons in the posterior lateral ganglion.
• Subcellular Localization: This DYF-5::GFP fusion could be detected uniformly in axons, cell bodies, and dendrites. In addition, authors observed strong fluorescence at the transition zones, which connect the cilia with the dendrites, and weak fluorescence uniformly in the cilia.

• Primary Identifier: Expr9619
• Pattern: ZK418.3 is expressed in amphid, phasmid, and labial neurons.

• Primary Identifier: Marker49
• Remark: Picture: N.A. Reporter gene fusion type not specified.
• Pattern: Expressed in anterior neurons, including AIY, AIZ, RID, M5, ASI, and labial sensory neurons, VNC motorneurons, midbody neurons HSN, CAN, and PVM, tail neurons DVB, DVC, and PDB, and the nonneuronal excretory cell, uterine muscles. -- according to pers. comm. from Oliver Hobert.

• Primary Identifier: Expr3726
• Pattern: Strong GFP signals in most ciliated cells, including amphid, phasmid, and labial-quadrant neurons.

• Primary Identifier: Expr3730
• Pattern: Strong GFP signals in most ciliated cells, including amphid, phasmid, and labial-quadrant neurons.

• Primary Identifier: Expr3734
• Subcellular Localization: GFP-tagged Y37E3.5 associate with ciliary axonemes in both head (amphids, labials) and tail (phasmids) neurons, with relatively little localization to cell bodies, axons, or dendrites.

• Primary Identifier: Expr3720
• Pattern: In C. elegans males, nph-4::GFP expression in the head was seen in the amphid neurons, the outer labial neurons, and a cell group that could be compatible with the male-specific CEM neurons. In the male tail, nph-4::GFP expression was seen in the lumbar and cloacal ganglia. nph-4 expression in hermaphrodites was found in ciliated amphid neurons, the outer labial neurons, and the phasmid neurons in the tail. Developmental regulation of expression for nph-4::GFP was found to be similar to nph-1, appearing at the 1.5-fold stage and lasting through adulthood.

• Primary Identifier: Expr8851
• Remark: Picture: Fig 3.
• Pattern: Neuronal Expression: labial sensory, CAN, phasmid sheath, a few head neurons. Non-neuronal Expression: seam cells, pharyngeal marginal and muscle cells, arcade cells.

• Primary Identifier: Expr11367
• Pattern: SNF-3::GFP transgenic worms displayed strong expression in the excretory canal, tail hypodermal cells, epidermis and vulval epithelia cells. SNF-3 was also expressed in some neurons, including the excretory canal-associated neuron, and some sensory neurons in the head including ILs, OLs, ADE and AQR.

• Primary Identifier: Expr3135
• Pattern: C47A10.6 expressed in both head (labial) and tail neurons (phasmid PHCL/R). C47A10.6 also showed medium to strong expression in scattered nonchemosensory neurons.

• Primary Identifier: Expr3727
• Pattern: Strong GFP signals in most ciliated cells, including amphid, phasmid, and labial-quadrant neurons.

• Primary Identifier: Expr8176
• Remark: Picture: Figure 4C.
• Pattern: GFP fluorescence was observed in most ciliated neurons, including neurons of the amphid, phasmid, and labial sensilla, as well as the neurons AQR, PQR, ADE, and PDE.

• Primary Identifier: Expr864
• Remark: Reporter gene fusion type not specified.
• Pattern: Expressed in bean-stage embryo, two-fold elongated embryo, four-fold elongated embryo, L1-L3. Expressed in the nerve ring: more than 8 symmetric pairs of neurons. Expressed in sensory neurons: amphid sensory neurons, labial neurons. Expressed in other neurons: ventral nerve cord, tail neurons. Expressed in non-neuronal tissues: pharynx, vulva.

• Primary Identifier: Expr3723
• Pattern: Expression in hermaphrodites was most prominent in the head region (amphid and inner/outer labial neurons), in the tail region (in both phasmid neurons), and in the mid-body ciliated neuronal cell PDE. Strong GFP signals were also detected in the male tail-ray neurons, all of which are ciliated. GFP expression was not detected in non-ciliated interneurons or motor neurons of the hermaphrodite tail or mid-body, or in any other tissues. The earliest point during development where expression was observed, at the 1.5-fold stage, correlates with the onset of ciliogenesis, and expression levels predictably increase as embryos develop to the 3-fold stage.

• Primary Identifier: Expr3719
• Pattern: In C. elegans hermaphrodites, nph-1::GFP expressed in the ciliated amphid neurons, the outer labial neurons, and the two phasmid neurons in the tail. In addition, early expression of nph-1::GFP in transgenic embryos was shown. The earliest point of observation during development was the 1.5-fold embryonic stage. In C. elegans males, nph-1::GFP expression in the head was detected in amphid neurons and in a second group of neurons that could not be assigned with certainty but that may be compatible with the male-specific CEM neurons. In the male tail, nph-1::GFP expression was found in the cloacal and lumbar ganglia. GFP expression in the lumbar ganglia was interpreted to be in the ninth sensory ray neuron. Expression in the cloacal ganglia could not be assigned with certainty.

• Primary Identifier: Expr3732
• Pattern: Expressed in most amphid, both phasmid, and several labial-quadrant neurons.

• Primary Identifier: Expr8772
• Remark: Picture: Fig 4, Fig S2E.
• Subcellular Localization: HYLS-1 localized to punctate structures in amphid and labial/cephalic neurons. This punctate staining was absent in hyls-1(D) worms and was fully restored. HYLS-1 puncta were closely apposed to the short stretches of NPH-4:YFP, a marker for the ciliary transition zone, indicating that HYLS-1 localizes to a discrete structure at the base of cilia. This result was confirmed using CHE-GFP, an IFT component that localizes to the transition zone and along the ciliary axoneme. Localization to the base of the cilium was also observed in phasmid neurons. Thus, HYLS-1 localizes to a discrete structure at the base of the mature cilium.

• Primary Identifier: Expr1618
• Pattern: A high proportion of PKC2 polypeptides is associated with the particulate fraction in newly-hatched (early L1) C. elegans and L3 and L4 larvae.
• Subcellular Localization: In mid-L1 and L2 larvae, as well as young adult nematodes, PKC2 isoforms are nearly uniformly dispersed between cytosol and organelles and/or cytoskeleton. In contrast, 70% of PKC2 isoforms is isolated in cytosol from egg-laying adults.

• Primary Identifier: Expr13692
• Pattern: A strain carrying an ins-11 transcriptional reporter construct (ins-11p::GFP) exhibited only a low constitutive fluorescence in adults, in the nerve ring, labial neurons and most obviously in the intestine.

• Primary Identifier: Expr865
• Remark: Reporter gene fusion type not specified.
• Pattern: Expressed in: four-fold elongated embryo L1-L4, adult. Expressed in the nerve ring: 4-8 symmetric pairs of neurons. Expressed in sensory neurons: amphid sensory neurons, labial neurons. Expressed in other neurons: ventral nerve cord, neurons with lateral processes and/or cell bodies, dorsal nerve cord neurons, observed by dorsal andor circumferential processes.

• Primary Identifier: Expr866
• Remark: Reporter gene fusion type not specified.
• Pattern: Expressed in two-fold elongated embryo, four-fold elongated embryo, L1-L4, adult. Expressed in the nerve ring: 4-8 symmetric pairs of neurons. Expressed in sensory neurons: amphid sensory neurons, labial neurons. Expressed in other neurons: ventral nerve cord, dorsal nerve cord neurons, observed by dorsal andor circumferential processes. tail neurons. Expressed in non-neuron tissues: hypodermis.

• Primary Identifier: Expr867
• Remark: Reporter gene fusion type not specified.
• Pattern: Expressed in two-fold elongated embryo, four-fold elongated embryo, L1-L4, adult. Expressed in the nerve ring: 4-8 symmetric pairs of neurons. Expressed in sensory neurons: amphid sensory neurons, labial neurons. Expressed in other neurons: ventral nerve cord, neurons with lateral processes andor cell bodies, tail neurons. Expressed in non-neuron tissues: vulva.

• Primary Identifier: Expr868
• Remark: Reporter gene fusion type not specified.
• Pattern: Expressed in two-fold elongated embryo, four-fold elongated embryo, L1-L4, adult. Expressed in the nerve ring: 2 symmetric pairs of neurons. Expressed in sensory neurons: amphid sensory neurons, labial neurons. Expressed in other neurons: ventral nerve cord, tail neurons.

• Primary Identifier: Expr869
• Remark: Reporter gene fusion type not specified.
• Pattern: Expressed in four-fold elongated embryo, L1-L4, adult. Expressed in the nerve ring: 4-8 symmetric pairs of neurons. Expressed in sensory neurons: amphid sensory neurons, labial neurons. Expressed in other neurons: ventral nerve cord, tail neurons.

• Primary Identifier: Expr870
• Remark: Reporter gene fusion type not specified.
• Pattern: Expressed in four-fold elongated embryo, L1-L4, adult. Expressed in the nerve ring: 4-8 symmetric pairs of neurons. Expressed in sensory neurons: amphid sensory neurons, labial neurons. Expressed in other neurons: ventral nerve cord, tail neurons. Expressed in non-neuron tissues: vulva.

• Primary Identifier: Expr875
• Remark: Reporter gene fusion type not specified.
• Pattern: Expressed in four-fold elongated embryo, L1-L4, adult. Expressed in the nerve ring: more than 8 symmetric pairs of neurons. Expressed in sensory neurons: amphid sensory neurons, labial neurons. Expressed in other neurons: ventral nerve cord, neurons with lateral processes and/or cell bodies, tail neurons.

• Primary Identifier: Expr876
• Remark: Reporter gene fusion type not specified.
• Pattern: Expressed in four-fold elongated embryo, L1-L4, adult. Expressed in the nerve ring: 2 symmetric pairs of neurons. Expressed in sensory neurons: amphid sensory neurons, labial neurons. Expressed in other neurons: ventral nerve cord.

• Primary Identifier: Expr1248
• Pattern: GFP signals were observed in the head neurons only, which appeared to be inner labial neurons or outer labial neurons. GFP also expressed in other head neurons. These neurons seem to be interneurons which connect sensory neurons to motor neurons.

• Primary Identifier: Expr12682
• Pattern: F47G4.5/KATNBL1 expression was mostly restricted to amphid and phasmid ciliated neurons, as well as several ciliated labial/quadrant neurons that send identifiable dendritic processes to the nematode nose tip.

0 Life Stages

3 Parents

Definition	Name	Synonym	Primary Identifier
neuron type, neurons that have ciliated nerve endings.	ciliated neuron		WBbt:0006816
	outer labial sensillum		WBbt:0005501
neuron that senses and responds to mechanical stimuli, such as touch.	mechanosensory neuron		WBbt:0008431