WormMine: ExpressionPattern Expr16258

• Pattern: For lin-39 and mab-5, previous work reported their partially overlapping expression in the ventral cord motor neurons (MNs). In this study, we used two fosmid reporters wgIs18[lin39::EGFP] and wgIs27[mab-5::EGFP] to map their expression to the single-cell resolution among the 75 motor neurons (MNs), which include 54 cholinergic MNs, 19 GABAergic MNs, and 2 serotonergic MNs with stereotypical positions. These MNs can be further classified into eight neuron classes (DA, DB, VA, VB, AS, VC, DD, and VD). By crossing the GFP reporters with mCherry strains labelling cholinergic or GABAergic neurons in the ventral cord, we identified lin-39 expression in DA2-5, DB2-7, VA3-8, VB4-9, AS2-8, VC1-6, DD2-6, and VD3-12 and mab-5 expression in DA4-8, DB5-7, VA6-11, VB8-11, AS5-11, VC3-6, DD2-6, and VD2-12. Both lin-39 and mab-5 expression were generally weaker in more anterior MNs. Interestingly, for cholinergic MNs, mab-5 and lin-39 expression only overlapped in a set of mid-body MNs; MNs more anterior to this region expressed only lin-39 and MNs more posterior expressed only mab-5. For GABAergic MNs (DD and VD), however, lin-39and mab-5 expression overlapped entirely. Outside of the ventral nerve cord, lin-39 was expressed in AQR and AIYL/R in the head and AVM, SDQL/R, PDEL/R, and PVDL/R neurons along the body; mab-5 was expressed in the AVL in the head, SDQL in the mid-body region, and PQR neuron in the tail.
• Primary Identifier: Expr16258

48 Anatomy Terms

Definition	Name	Synonym	Primary Identifier
Neuron class of one sensory neuron, basal body, not part of a sensillum, projects into preanal gangion.	PQR	lineage name: QL.ap	WBbt:0004096
Hermaphrodite specific ventral cord motor neuron innervates vulval muscles and ventral body muscles	VC4	lineage name: P6.aap	WBbt:0004617
Hermaphrodite specific ventral cord motor neuron innervates vulval muscles and ventral body muscles	VC5	lineage name: P7.aap	WBbt:0004613
Ventral cord motor neuron, innervates ventral body muscles	VB9	lineage name: P8.aaap	WBbt:0004627
Ventral cord motor neuron, innervates ventral body muscles	VB10	lineage name: P9.aaap	WBbt:0004625
Ventral cord motor neuron, innervates ventral body muscles	VB11	lineage name: P10.aaap	WBbt:0004623
Ventral cord motor neuron, innervates ventral body muscles	VB8	lineage name: P7.aaap	WBbt:0004629
Ventral cord motor neurons, innervate dorsal muscles	DB5	lineage name: ABplpapappp	WBbt:0004842
Ventral cord motor neurons, innervate dorsal muscles	DB6	lineage name: ABplppaappp	WBbt:0004841
Ventral cord motor neurons, innervate dorsal muscles	DB7	lineage name: ABprppaappp	WBbt:0004840
Ventral cord motor neurons, innervate dorsal muscles	DA7	lineage name: ABprpppaaap	WBbt:0004859
Ventral cord motor neurons, innervate dorsal muscles	DA4	lineage name: ABplppapapp	WBbt:0004865
Ventral cord motor neurons, innervate dorsal muscles	DA5	lineage name: ABprppapapp	WBbt:0004863
Ventral cord motor neurons, innervate dorsal muscles	DA6	lineage name: ABplpppaaap	WBbt:0004861
Neuron class of one ring and ventral cord interneuron, few synapses.	AVL	lineage name: ABprpappaap	WBbt:0003843
Hermaphrodite specific ventral cord motor neuron innervates vulval muscles and ventral body muscles	VC6	lineage name: P8.aap	WBbt:0004611
Hermaphrodite specific ventral cord motor neuron innervates vulval muscles and ventral body muscles	VC3	lineage name: P5.aap	WBbt:0004618
Posterior lateral interneuron, process projects into ring	SDQL	lineage name: QL.pap	WBbt:0004993
Ventral cord motor neurons, reciprocal inhibitors, chnage synaptic pattern during postembryonic development	DD6	lineage name: ABprppapppp	WBbt:0004824
Ventral cord motor neuron, innervates dorsal muscles, no ventral counterpart	AS6	lineage name: P6.apa	WBbt:0003910
Ventral cord motor neuron, innervates dorsal muscles, no ventral counterpart	AS5	lineage name: P5.apa	WBbt:0003911
Ventral cord motor neuron, innervates dorsal muscles, no ventral counterpart	AS11	lineage name: P11.apa	WBbt:0003905
Ventral cord motor neuron, innervates dorsal muscles, no ventral counterpart	AS9	lineage name: P9.apa	WBbt:0003907
Ventral cord motor neuron, innervates dorsal muscles, no ventral counterpart	AS10	lineage name: P10.apa	WBbt:0003906
Ventral cord motor neuron, innervates dorsal muscles, no ventral counterpart	AS7	lineage name: P7.apa	WBbt:0003909
Ventral cord motor neuron, innervates dorsal muscles, no ventral counterpart	AS8	lineage name: P8.apa	WBbt:0003908
Ventral cord motor neurons, reciprocal inhibitors, chnage synaptic pattern during postembryonic development	DD2	lineage name: ABprppappap	WBbt:0004838
Ventral cord motor neuron, innervates ventral body muscles	VA11	lineage name: P11.aaaa	WBbt:0004647
Ventral cord motor neuron, innervates ventral body muscles, probably reciprocal inhibitor	VD12	lineage name: P11.app	WBbt:0004587
Ventral cord motor neuron, innervates ventral body muscles, probably reciprocal inhibitor	VD11	lineage name: P10.app	WBbt:0004589

1 Genes

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00003102	mab-5	C08C3.3	Caenorhabditis elegans

0 Life Stages