| Primary Identifier | Expr15060 | Subcellular Localization | C06A5.6, which we subsequently named SIMR-1, formed distinct perinuclear foci in germ cells, either adjacent to or colocalizing with Mutator foci. SIMR-1 foci are closely associated with both P granules and with Z granules (100% of the time with P granules, n=56 SIMR-1 foci, and 100% of the time with Z granules, n=62 SIMR-1 foci). However, we found that SIMR-1 foci do not fully colocalize with either structure, and in some cases multiple SIMR-1 foci can associate with a single focus of another granule type. SIMR-1 foci do appear to be more closely associated with Z granules than with P granules and quantification of distances between fluorescence centers of each foci supports this observation. Following immunostaining, we observed that SIMR-1 and RSD-2 were highly coincident, suggesting SIMR-1 and RSD-2 may localize to the same perinuclear structure. These results indicate that SIMR-1 and RSD-2 interact closely with one another at perinuclear foci near but distinct from Mutator foci, P granules and Z granules. Because these foci are distinct from previously characterized structures, we are calling them SIMR foci. |
| Definition | Name | Synonym | Primary Identifier |
|---|---|---|---|
| a cell, of either sex, directly concerned in the production of a new organism. | germ cell | WBbt:0006796 |
| WormBase Gene ID | Gene Name | Sequence Name | Organism |
|---|---|---|---|
| WBGene00015504 | simr-1 | C06A5.6 | Caenorhabditis elegans |
