| WormBase ID | WBRNAi00107837 | Genotype | UNC-119::mCherry; gld-1(RNAi) |
| Phenotype Remark | "To assess neuronal differentiation, the tumor was induced in the pan-neuronal marker (UNC-119::mCherry) strain by gld-1 RNAi and maximum z-projections covering whole gonad arms were used to score the area occupied by UNC-119::mCherry-expressing cells. Concomitant downregulation of either lgg-3 or atg-7 -- both required for autophagy (Fig 3C) -- leads to a reduction of the area occupied by UNC-119::mCherry-expressing cells in the tumor by around 50% and 30%, respectively (Fig 4B and C). Therefore, depletion of autophagy results in impairment of neuronal differentiation within the germline tumor." | Remark | (Figure 4B,4C) atg-7 RNAi. Exact sequence used for RNAi not stated by authors, Ahringer laboratory clone used for curation. |
| WormBase Gene ID | Gene Name | Sequence Name | Organism |
|---|---|---|---|
| WBGene00010882 | atg-7 | M7.5 | Caenorhabditis elegans |
| Identifier | Name | Description |
|---|---|---|
| WBPhenotype:0000354 | cell differentiation variant | Variations in the processes leading to the specialization of cell. Differentiation impacts diverse cellular properties such as size, shape, polarity, gene expression and responsiveness to signals/cues. |
