WormMine: RNAi WBRNAi00101795

• WormBase ID: WBRNAi00101795
• Genotype: rrf-3(pk1426) II; ccIs4438 (intrinsic CC(CoelomoCyte)::gfp) III
• Phenotype Remark: Postembryonic sys-1 RNAi results in both fewer M-lineage derived coelomocytes (in 6.9% of animals) and extra M-lineage derived coelomocytes (in 51.2% of animals) as determined by CC::GFP. Authors report that some of the extra coelomocytes on the dorsal side of the M lineage in sys-1(RNAi) animals are due to an extra round of cell division by the cells M.d(l/r)pp and/or M.d(l/r)pa. In other cases the extra coelomocytes were the result of the body wall muscle (BWM) fate of M.d(l/r)pp being transformed to the coelomocyte (CC) fate like that of the anterior sister cell M.d(l/r)pa.
• Remark: (Figure 4, S2, Table 2) sys-1 RNAi-P (postembryonic RNAi)

1 Organism

• Name: Caenorhabditis elegans
• Taxon Id: 6239

1 Data Sets

• WormBaseAcedbConverter

1 Inhibits Gene

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00006379	sys-1	T23D8.9	Caenorhabditis elegans

3 Inhibits Predicted Gene

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:T23D8.9a	T23D8.9a	2436	I: 9980494-9980576
CDS:T23D8.9b	T23D8.9b	720	I: 9982656-9982683
CDS:T23D8.9c	T23D8.9c	2037	I: 9980494-9980576

1 Laboratories

Primary Identifier
LW

6 Phenotype

Identifier	Name	Description
WBPhenotype:0000095	M lineage variant	The descendants of the M precursor cell exhibit variations in developmental programs compared to their counterparts in control animals. In C. elegans the M lineage is a postembryonic mesodermal lineage.
WBPhenotype:0000961	pattern of transgene expression variant	Any variation in the cellular or subcellular pattern of expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to its expression in control animals.
WBPhenotype:0000414	cell fate transformation	The cell takes on a different identity from which it was initially committed.
WBPhenotype:0001912	fewer coelomocytes	The number of coelomocytes are reduced compared to control animals. Coelomocytes are free-floating spherical cells lying in the pseudocoelomic cavity of animals that can endocytose many compounds.
WBPhenotype:0000358	extra cell division postembryonic	Animals execute supernumerary cell divisions post-hatching.
WBPhenotype:0001913	excess coelomocytes	The number of coelomocytes are increased compared to control animals. Coelomocytes are free-floating spherical cells lying in the pseudocoelomic cavity of animals that can endocytose many compounds.

0 Phenotype _ Not _ Observed

1 Reference

First Author	Title	Year	Journal	Volume	Pages	PubMed ID
						WBPaper00033137

0 Strain