WormMine: RNAi WBRNAi00097885

• WormBase ID: WBRNAi00097885
• Genotype: eri-1(mg366); juIs76 [Punc-25::GFP] (marker for GABAergic neurons)
• Phenotype Remark: GABA neurons (visualized with unc-25::GFP) degenerate in coq-1 knockdown animals, and cell bodies, viewed under differential interference contrast (DIC), demonstrated the swollen appearance characteristic of necrotic cell death. GABAergic processes in the ventral nerve cord, circumferential commissures and GABAergic processes in the dorsal cord appear discontinuous with apparent breaks. These morphological defects first appeared in late larval development and progressed as animals aged, thereby mirroring the age-dependent pattern of the Unc phenotype.
• Remark: (Figure 2A-D) coq-1 RNAi. Exact sequence used for RNAi not stated by authors, Ahringer laboratory clone used for curation.

1 Organism

• Name: Caenorhabditis elegans
• Taxon Id: 6239

1 Data Sets

• WormBaseAcedbConverter

1 Inhibits Gene

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00000761	coq-1	C24A11.9	Caenorhabditis elegans

1 Inhibits Predicted Gene

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:C24A11.9	C24A11.9	1182	I: 5413127-5413207

1 Laboratories

Primary Identifier
NC

5 Phenotype

Identifier	Name	Description
WBPhenotype:0000179	neuron degeneration	Cells specialized for receiving, conducting and transmitting impulses in the nervous system are observed to undergo a dramatic decrease in cell volume, collapse of the vacuoles and processes, and complete disintegration of the plasma membrane and most organelles.
WBPhenotype:0001397	necrotic cell death increased	Animals exhibit an increase in the cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents, compared to control.
WBPhenotype:0000515	ventral nerve cord development variant	Variations in any process whose specific outcome is the development and/or maintenance of the ventral nerve cord.
WBPhenotype:0000539	dorsal nerve cord development variant	Variations in the progression of the anatomical structures that consist of processes of ventral cord motor neurons that send commissures to the dorsal side, as well as processes of certain head and tail neurons, over time from initial formation to mature structure compared to control (Wormatlas).
WBPhenotype:0000014	cord commissures variant	Variations in the structure, organization or path of axon tracts that grow circumferentially around the animal in a single, directed trajectory to bridge the ventral and dorsal cords, compared to control animals.

0 Phenotype _ Not _ Observed

1 Reference

First Author	Title	Year	Journal	Volume	Pages	PubMed ID
						WBPaper00036704

0 Strain