WormMine: RNAi WBRNAi00101912

• WormBase ID: WBRNAi00101912
• Genotype: L-AChR(gf) (ufIs6)
• Phenotype Remark: This RNAi was able to suppress the locomotion phenotypes found in L-AChR(gf) animals. L-AChR(gf) enhances synaptic activation of muscles by increasing L-AChR function.
• Remark: The authors wanted to enhance synaptic activation of muscles by increasing L-AChR function, thus they introduced an amino acid change at a highly conserved position in the pore-lining M2 regions of cDNAs encoding the UNC-29, UNC-38 and LEV-1 subunits. They constructed a strain (ufIs6) stably expressing the unc-29(L/S), unc-38(V/S) and lev-1(L/S) cDNAs under control of the muscle-specific myo-3 promoter, and refer to this as L-AChR(gf).

1 Organism

• Name: Caenorhabditis elegans
• Taxon Id: 6239

1 Data Sets

• WormBaseAcedbConverter

1 Inhibits Gene

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00003740	nlp-2	T24D8.5	Caenorhabditis elegans

1 Inhibits Predicted Gene

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:T24D8.5	T24D8.5	516	X: 2344059-2344302

1 Laboratories

Primary Identifier
IZ

1 Phenotype

Identifier	Name	Description
WBPhenotype:0000643	locomotion variant	Animals exhibit deviations in self-propelled movement on a solid medium compared to control animals.

0 Phenotype _ Not _ Observed

1 Reference

First Author	Title	Year	Journal	Volume	Pages	PubMed ID
						WBPaper00045671

0 Strain