WormMine

WS295

Intermine data mining platform for C. elegans and related nematodes

RNAi :

WormBase ID  WBRNAi00110364 Genotype  lim-7p:acs-1(hairpinRNAi)
Phenotype Remark  "In contrast, when acs-1 expression was inhibited in the somatic gonad by somatic gonad-specific RNAi, the remaining expression of acs-1 in the intestine, neurons, and possibly other tissues was insufficient to prevent the Emb phenotype (Materials and Methods; Supplemental Fig. S2ad-ag)." Figure caption: "DIC images illustrating the gonadal and embryonic phenotype in lim-7Prom:acs-1(hpRNAi) animals. Most of the affected animals had prominent gonadal defects and were sterile (ad, ae). Image (af) shows the Emb phenotype of the affected animals, which is similar to those observed in the acs-1(RNAi)C17ISO embryos (Figure 3I)." Remark  (Supplemental Fig. S2ad-ag) somatic gonad-specific acs-1 (hairpin) RNAi. Exact sequence used for RNAi not stated by authors, spliced coding region sequence of gene used for curation.
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1 Organism

Name Taxon Id
Caenorhabditis elegans 6239

1 Data Sets

Name URL
WormBaseAcedbConverter  

1 Inhibits Gene

WormBase Gene ID Gene Name Sequence Name Organism
WBGene00018488 acs-1 F46E10.1 Caenorhabditis elegans

3 Inhibits Predicted Gene

WormMine ID Sequence Name Length (nt) Chromosome Location
CDS:F46E10.1c F46E10.1c 1737   V: 6529269-6529439
CDS:F46E10.1a F46E10.1a 1872   V: 6525095-6525136
CDS:F46E10.1b F46E10.1b 1794   V: 6527511-6527520

0 Laboratories

3 Phenotype

Identifier Name Description
WBPhenotype:0000688 sterile Animals generate defective gametes, are otherwise unable to reproduce or they generate progeny that are unable to reproduce.
WBPhenotype:0000050 embryonic lethal Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die.
WBPhenotype:0000691 gonad development variant Variations in the progression of the organ that produces gametes over time, from its formation to the mature structure compared to control.

0 Phenotype _ Not _ Observed

1 Reference

First Author Title Year Journal Volume Pages PubMed ID
            WBPaper00040893

0 Strain