WormMine: RNAi WBRNAi00110261

• WormBase ID: WBRNAi00110261
• Genotype: zcIs39 [dve-1p::dve-1::gfp]; cco-1(RNAi)
• Phenotype Remark: To understand whether LIN-65 is required for establishing or perpetuating UPRmt into adulthood, we tested the timing requirements of lin-65 in mediating DVE-1 puncta formation. Animals in which mitochondrial stress was induced during development (cco-1 RNAi during development), but which had lin-65 reduced only during adulthood retained nuclear DVE-1::GFP puncta formation (Figure 4I). In contrast, animals with both mitochondrial stress and reduced lin-65 activity only during development completely suppressed DVE-1::GFP puncta formation in adulthood (Figure 4I). These data indicate that lin-65 likely establishes an epigenetic mark on H3K9 during development, allowing for DVE-1 puncta formation in response to mitochondrial stress."
• Remark: (Figure 4I) lin-65 RNAi. RNAi strains were from the Vidal library if present, or the Ahringer library if absent from the Vidal library.

1 Organism

• Name: Caenorhabditis elegans
• Taxon Id: 6239

1 Data Sets

• WormBaseAcedbConverter

1 Inhibits Gene

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00022149	lin-65	Y71G12B.9	Caenorhabditis elegans

3 Inhibits Predicted Gene

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:Y71G12B.9a	Y71G12B.9a	2187	I: 1755330-1755462
CDS:Y71G12B.9b	Y71G12B.9b	1722	I: 1755330-1755462
CDS:Y71G12B.9c	Y71G12B.9c	471	I: 1763639-1763845

0 Laboratories

1 Phenotype

Identifier	Name	Description
WBPhenotype:0000679	transgene subcellular localization variant	Any variation in the subcellular localization of a gene product produced by DNA coded for by exogenous genetic material that has been introduced into the organism compared to its expression in control animals.

0 Phenotype _ Not _ Observed

1 Reference

First Author	Title	Year	Journal	Volume	Pages	PubMed ID
						WBPaper00050412

0 Strain