WormMine: RNAi WBRNAi00097862

• WormBase ID: WBRNAi00097862
• Genotype: Pced-1::CCZ-1::YFP
• Phenotype Remark: vps-18 RNAi resulted in visible fluorescent halos of CCZ-1::YFP in phagosomes engulfing apoptotic cell corpses (as in wild type), albeit to a lesser extent than wild type. The presence of the CCZ-1::YFP halos suggests that CCZ-1 acts upstream of VPS-18 in the phagosome maturation pathway.
• Remark: (Figure 3B, 3C) vps-18 RNAi. Exact sequence used for RNAi not stated by authors, Ahringer laboratory clone used for curation.

1 Organism

• Name: Caenorhabditis elegans
• Taxon Id: 6239

1 Data Sets

• WormBaseAcedbConverter

1 Inhibits Gene

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00021058	vps-18	W06B4.3	Caenorhabditis elegans

1 Inhibits Predicted Gene

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:W06B4.3	W06B4.3	3081	II: 4461131-4461204

1 Laboratories

Primary Identifier
JCP

2 Phenotype

Identifier	Name	Description
WBPhenotype:0000679	transgene subcellular localization variant	Any variation in the subcellular localization of a gene product produced by DNA coded for by exogenous genetic material that has been introduced into the organism compared to its expression in control animals.
WBPhenotype:0001846	phagosome maturation defective	Early phagosomes fail to undergo the maturation process following the ingestion of particulate material by phagocytosis; During maturation, phagosomes acquire markers of late endosomes and lysosomes.

0 Phenotype _ Not _ Observed

1 Reference

First Author	Title	Year	Journal	Volume	Pages	PubMed ID
						WBPaper00036342

0 Strain