Any decrease in the intensity of expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to its expression in control animals.
Any variation in the subcellular localization of a gene product produced by DNA coded for by exogenous genetic material that has been introduced into the organism compared to its expression in control animals.
Any variation in the form or composition of membrane bound organelles, known as lysosome-related organelles (LROs) that, like lysosomes, have an acidic interior and generally act to digest components of the cell but are distinct in function, composition, and morphology, compared to control.