Early embryos exhibit defects in the placement of the array of microtubules and associated molecules that form between opposite poles of a eukaryotic cell during mitosis or meiosis.
Cells exhibit variations in the process whereby a cell progresses from metaphase to anaphase during mitosis, compared to control. Metaphase is the second stage of chromosome segregation in the cell cycle where chromosomes become aligned on the equatorial plate of the cell and anaphase is the stage where sister chromatids separate and migrate towards the poles of the spindle.
