WormMine

WS295

Intermine data mining platform for C. elegans and related nematodes

RNAi :

WormBase ID  WBRNAi00110127 Genotype  glp-1(oz112)
Phenotype Remark  Authors state cir-1 is necessary for proper germline proliferation. Evidence comes from the partial suppression of germ line tumors in glp-1(oz112gf) mutants after cir-1 RNAi treatment. glp-1(oz112gf) mutants produce germ line tumors through accumulation of more than 4000 mitotic germ nuclei without showing any sign of meiosis. When treated with cir-1(RNAi), glp-1(gf) mutants are still tumorous, but their germ lines contained significantly less germ cells. Remark  Exact sequence used for RNAi not stated by authors, spliced coding region of cir-1 (350-1050 nt) used for curation.
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1 Organism

Name Taxon Id
Caenorhabditis elegans 6239

1 Data Sets

Name URL
WormBaseAcedbConverter  

1 Inhibits Gene

WormBase Gene ID Gene Name Sequence Name Organism
WBGene00018892 cir-1 F55F8.4 Caenorhabditis elegans

1 Inhibits Predicted Gene

WormMine ID Sequence Name Length (nt) Chromosome Location
CDS:F55F8.4 F55F8.4 1683   I: 5653916-5654640

0 Laboratories

1 Phenotype

Identifier Name Description
WBPhenotype:0000812 germ cell development variant Variations in the progression of the immature germ cell over time, from its formation from precursors to the mature structure (gamete) compared to control.

0 Phenotype _ Not _ Observed

1 Reference

First Author Title Year Journal Volume Pages PubMed ID
            WBPaper00036278

0 Strain