WormMine

WS295

Intermine data mining platform for C. elegans and related nematodes

RNAi :

WormBase ID  WBRNAi00099081 Genotype  Pmed-1gfp::htcf4/pop-1(II+V)
Phenotype Remark  wrm-1(RNAi) in a transgenic strain expressing hTCF4/POP-1(II+V) causes the A-P asymmetric pattern of GFP::hTCF4/POP-1(II+V) fluorescence to be abolished in This shows a requirement of WRM-1 for A-P asymmetry and suggests that GFP::hTCF4/POP-1(II+V) responds to the Wnt/MAPK signal in the E blastomere by undergoing nuclear export following LIT-1 phosphorylation. htcf4/pop-1(II+V) codes for a chimeric proteins in which aa 54-327 of hTCF4 was replaced with aa 47-191 of POP-1. Remark  htcf4/pop-1(II+V) codes for a chimeric proteins in which aa 54-327 of hTCF4 was replaced with aa 47-191 of POP-1. Exact sequence used for RNAi not stated by authors, spliced coding region sequence of gene used for curation.

1 Organism

Name Taxon Id
Caenorhabditis elegans 6239

1 Data Sets

Name URL
WormBaseAcedbConverter  

1 Inhibits Gene

WormBase Gene ID Gene Name Sequence Name Organism
WBGene00006943 wrm-1 B0336.1 Caenorhabditis elegans

2 Inhibits Predicted Gene

WormMine ID Sequence Name Length (nt) Chromosome Location
CDS:B0336.1a B0336.1a 2391   III: 5722883-5722907
CDS:B0336.1b B0336.1b 2229   III: 5723639-5723782

1 Laboratories

Primary Identifier
TX

2 Phenotype

Identifier Name Description
WBPhenotype:0000104 cell polarity variant Contents or structures of a cell are no longer restricted/localized to their typical positions within the cell.
WBPhenotype:0000961 pattern of transgene expression variant Any variation in the cellular or subcellular pattern of expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to its expression in control animals.

0 Phenotype _ Not _ Observed

1 Reference

First Author Title Year Journal Volume Pages PubMed ID
            WBPaper00038377

0 Strain