WormMine: RNAi WBRNAi00066319

• WormBase ID: WBRNAi00066319
• Phenotype Remark: A similar lifespan extension was observed when animals were switched onto RNAi at different ages (egg, L1, L2, L3 ,L4 or young adults). Initiating daf-2 RNAi treatments later in adulthood, throughout the reproductive period, also extended lifespan, but the magnitude declined steadily, and became insignificant after about 6 days of adulthood. The authors interpret this to mean daf-2 is required during adulthood. To further this finding authors hatched animals on daf-2 RNAi and when they reached adulthood, they switched them to dcr-1 RNAi to turn off the RNAi process during adulthood and saw these animals did not have long lifespans.

1 Organism

• Name: Caenorhabditis elegans
• Taxon Id: 6239

1 Data Sets

• WormBaseAcedbConverter

1 Inhibits Gene

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00000898	daf-2	Y55D5A.5	Caenorhabditis elegans

5 Inhibits Predicted Gene

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:Y55D5A.5d	Y55D5A.5d	5400	III: 2995919-2996014
CDS:Y55D5A.5a	Y55D5A.5a	5541	III: 2995919-2996014
CDS:Y55D5A.5c	Y55D5A.5c	5787	III: 2995919-2996014
CDS:Y55D5A.5e	Y55D5A.5e	5313	III: 2995919-2996014
CDS:Y55D5A.5f	Y55D5A.5f	3111	III: 2995919-2996014

1 Laboratories

Primary Identifier
CF

1 Phenotype

Identifier	Name	Description
WBPhenotype:0000061	extended life span	The duration of viability in the adult phase of the life-cycle surpasses that of control animals.

0 Phenotype _ Not _ Observed

1 Reference

First Author	Title	Year	Journal	Volume	Pages	PubMed ID
						WBPaper00005488

1 Strain

WormBase ID
WBStrain00000001