WormMine: RNAi WBRNAi00088813

• WormBase ID: WBRNAi00088813
• Phenotype Remark: Several cells of the arrested dut-1(RNAi) embryos displayed characteristic apoptotic features, including highly condensed electron-dense chromatin structures as visualized by electron microscopy. Furthermore, a nearly twofold increase in the number of apoptotic cell corpses and TUNEL-positive cells was observed in dut-1(RNAi) embryos compared with the wild type.
• Remark: dut-1(RNAi); Authors do not explicitly state what clone or sequence was used to knockdown dut-1 by RNAi, but based on references to other papers, this experiment is annotated as using the Vidal dut-1 RNAi clone delivered by feeding.

1 Organism

• Name: Caenorhabditis elegans
• Taxon Id: 6239

1 Data Sets

• WormBaseAcedbConverter

1 Inhibits Gene

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00010609	dut-1	K07A1.2	Caenorhabditis elegans

1 Inhibits Predicted Gene

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:K07A1.2	K07A1.2	1476	I: 9585421-9585801

1 Laboratories

Primary Identifier
TTV

2 Phenotype

Identifier	Name	Description
WBPhenotype:0000050	embryonic lethal	Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die.
WBPhenotype:0000183	apoptosis increased	Any perturbation that causes an elevation in the frequency of cell death by apoptosis compared to control animals.

0 Phenotype _ Not _ Observed

1 Reference

First Author	Title	Year	Journal	Volume	Pages	PubMed ID
						WBPaper00038332

1 Strain

WormBase ID
WBStrain00000001