WormMine: RNAi WBRNAi00110357

• WormBase ID: WBRNAi00110357
• Phenotype Remark: "RNAi inhibition of either elo-5 or acs-1 from the time of hatching causes early larval arrest and lethality, which can be rescued by including C17ISO in the diet (Kniazeva et al. 2004, 2008). We found that with C17ISO supplementation, elo-5(RNAi) animals proliferated indefinitely, while acs-1(RNAi) animals grew as wild type for only one generation and produced only dead embryos (Emb phenotype) (Fig. 1B,C)."
• Remark: (Fig. 1B,C) acs-1(RNAi)

1 Organism

• Name: Caenorhabditis elegans
• Taxon Id: 6239

1 Data Sets

• WormBaseAcedbConverter

1 Inhibits Gene

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00018488	acs-1	F46E10.1	Caenorhabditis elegans

3 Inhibits Predicted Gene

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:F46E10.1c	F46E10.1c	1737	V: 6529269-6529439
CDS:F46E10.1a	F46E10.1a	1872	V: 6525095-6525136
CDS:F46E10.1b	F46E10.1b	1794	V: 6527511-6527520

0 Laboratories

1 Phenotype

Identifier	Name	Description
WBPhenotype:0000050	embryonic lethal	Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die.

0 Phenotype _ Not _ Observed

1 Reference

First Author	Title	Year	Journal	Volume	Pages	PubMed ID
						WBPaper00040893

0 Strain