WormMine: RNAi WBRNAi00110025

• WormBase ID: WBRNAi00110025
• Genotype: ccIs55 [unc-54::lacZ + sup-7(st5)]
• Phenotype Remark: "Next, we performed RNAi against a set of 10 knockdowns previously shown to produce embryonic lethality [icd-1 (inhibitor of celldeath), snr-6 (small nuclear ribonucleoprotein), npp-20 (nuclear pore complex protein), vha-9 (vaculolar ATPase), nap-1 (nucleosome assembly protein), ufd-1 (ubiquitin fusion degradation), fnta-1 (farnesyltransferase), pbs-2 (proteasome b-subunit), cyb-2.1 (cyclin B), and crn-1 (cell death related nuclease)]. In each case, we found embryonic lethality as expected. When these genes were knocked down in fully developed adults, we further found both increased protein degradation and loss of mitochondrial reticular structure but no defects in the sarcomere structure."
• Remark: ufd-1 RNAi. Exact sequence used for RNAi not stated by authors, Ahringer laboratory clone used for curation.

1 Organism

• Name: Caenorhabditis elegans
• Taxon Id: 6239

1 Data Sets

• WormBaseAcedbConverter

1 Inhibits Gene

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00006733	ufd-1	F19B6.2	Caenorhabditis elegans

2 Inhibits Predicted Gene

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:F19B6.2b	F19B6.2b	1011	IV: 12329512-12329651
CDS:F19B6.2a	F19B6.2a	1029	IV: 12329512-12329651

0 Laboratories

1 Phenotype

Identifier	Name	Description
WBPhenotype:0000120	protein expression reduced	Any change that results in lower than normal levels of protein expression compared to control animals.

0 Phenotype _ Not _ Observed

1 Reference

First Author	Title	Year	Journal	Volume	Pages	PubMed ID
						WBPaper00046120

0 Strain