WormMine: RNAi WBRNAi00086076

• WormBase ID: WBRNAi00086076
• Phenotype Remark: Centrosome duplication fails prior to the second mitotic division in sas-4(RNAi) embryos. In addition authors show that centriolar SAS-4 levels determine centrosome size. In all sas-4((RNAi) embryos microtubule dynamics and spindle assembly were identical to wild-type during the first mitotic division. However as sas-4(RNAi) embryos entered their second division, each daughter cell assembled only a single centrosomal microtubule aster. These single asters increased normally in size as the cells entered mitosis,and monopolar spindles were formed.

1 Organism

• Name: Caenorhabditis elegans
• Taxon Id: 6239

1 Data Sets

• WormBaseAcedbConverter

1 Inhibits Gene

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00004726	sas-4	F10E9.8	Caenorhabditis elegans

1 Inhibits Predicted Gene

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:F10E9.8	F10E9.8	2427	III: 8314576-8314864

1 Laboratories

Primary Identifier
TH

1 Phenotype

Identifier	Name	Description
WBPhenotype:0001903	centrosome biogenesis variant	Animals exhibit variations in the formation, maturation or disassembly of the centrosome (a subcellular body consisting of two centrioles embedded in a protein matrix). The centrosome serves as a microtubule organizing center as well as a regulator of cell-cycle progression.

0 Phenotype _ Not _ Observed

1 Reference

First Author	Title	Year	Journal	Volume	Pages	PubMed ID
						WBPaper00005739

0 Strain