RNAi resulted in increased expression of the PTCx transgene carrying a premature termination codon, indicative of defective mRNA surveillance machinery
Any increase in the intensity of expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to its expression in control animals.
Defects in the cellular machinery that targets aberrant mRNAs species (nonsense codons, splice errors, altered untranslated regions etc.) for degradation. In C. elegans, mutations in such loci often act as allele-specific non gene-specific recessive suppressors of certain allele phenotypes and cause abnormal morphogenesis of male and hermaphrodite genitalia.