WormMine: RNAi WBRNAi00114744

• WormBase ID: WBRNAi00114744
• Genotype: drIs28[myo-3p::GR50-GFP]
• Phenotype Remark: "Two independent paralysis assays showed that animals on dss-1(RNAi) exhibited reduced paralysis compared to the negative control EV(RNAi) (Figure 1B). In addition to these phenotypes, the other toxic DPR made via the C9orf72 repeat expansion mutation, (GR)50, showed similar results (Figure 1C). This decrease in C. elegans age-dependent paralysis following dss-1(RNAi) shows that dss-1 normally functions to facilitate (PR)50 and (GR)50 induced age-dependent paralysis... Two independent VSA [video speed analysis] trials showed increased motility in (PR)50 expressing animals on dss-1(RNAi) compared to EV(RNAi) (Figure 1D, F). (GR)50, showed similar results (Figure 1E, G)."
• Remark: dss-1 (WBGene00022492) RNAi, ORFeome clone

1 Organism

• Name: Caenorhabditis elegans
• Taxon Id: 6239

1 Data Sets

• WormBaseAcedbConverter

1 Inhibits Gene

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00022492	dss-1	Y119D3B.15	Caenorhabditis elegans

1 Inhibits Predicted Gene

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:Y119D3B.15	Y119D3B.15	249	III: 1194668-1194805

0 Laboratories

1 Phenotype

Identifier	Name	Description
WBPhenotype:0002605	dipeptide repeat protein toxicity suppressed	Normally toxic dipeptide repeat proteins appear to be less toxic to animals, compared to control animals.

0 Phenotype _ Not _ Observed

1 Reference

First Author	Title	Year	Journal	Volume	Pages	PubMed ID
						WBPaper00059748

0 Strain