WormMine: RNAi WBRNAi00084889

• WormBase ID: WBRNAi00084889
• Phenotype Remark: KNL-1 depletion led to visible segregation defects during both meiotic divisions; tight metaphase plates failed to form and one or more lagging chromosomes were evident during meiotic anaphase I and II. Chromosome counting revealed significant aneuploidy in meiosis II embryos. In KNL-1-depleted embryos undergoing meiosis I and II, chromosomes were improperly oriented. Chromosomes failed to orient relative to the spindle axis in KNL-1-depleted embryos, and instead maintained an early prometaphase-like configuration. chromosome masses in KNL-1-depleted embryos separated at a speed comparable to controls

1 Organism

• Name: Caenorhabditis elegans
• Taxon Id: 6239

1 Data Sets

• WormBaseAcedbConverter

1 Inhibits Gene

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00002231	knl-1	C02F5.1	Caenorhabditis elegans

1 Inhibits Predicted Gene

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:C02F5.1	C02F5.1	3033	III: 8250636-8250781

0 Laboratories

5 Phenotype

Identifier	Name	Description
WBPhenotype:0001882	aneuploidy	Any variation in the number of chromosomes in a cell compared to control.
WBPhenotype:0001348	chromosome morphology variant	Variations in the form or composition of a structure in the cell nucleus which contains the genetic material encoded as DNA and surrounded by histone proteins and other regulatory elements compared to control. In C. elegans the normal cell contains 5 pairs of 'autosomes' and one or two X chromosomes (Wormatlas).
WBPhenotype:0001499	meiotic chromosome segregation variant	Variations in the process by which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle, compared to control.
WBPhenotype:0001875	anaphase bridging	Chromosomal masses fail to fully separate and remained linked during anaphase.
WBPhenotype:0001584	chromosome alignment variant	Any variation in the movement of chromosomes to the spindle equator during mitosis compared to control animals.

0 Phenotype _ Not _ Observed

1 Reference

First Author	Title	Year	Journal	Volume	Pages	PubMed ID
						WBPaper00037073

0 Strain