WormMine: RNAi WBRNAi00077956

• WormBase ID: WBRNAi00077956
• Phenotype Remark: Larvae often had morphogenic abnormalities along with vacuoles indicative of general cell death.
• Remark: Authors used feeding, soaking and injection methods to deliver RNAi. All three methods showed the same phenotypes with variable penetrance. Injection gave the strongest phenotypes.

1 Organism

• Name: Caenorhabditis elegans
• Taxon Id: 6239

1 Data Sets

• WormBaseAcedbConverter

1 Inhibits Gene

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00003650	nhr-60	F57A10.5	Caenorhabditis elegans

1 Inhibits Predicted Gene

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:F57A10.5	F57A10.5	1332	V: 15770361-15770620

1 Laboratories

Primary Identifier
KV

8 Phenotype

Identifier	Name	Description
WBPhenotype:0000351	failure to hatch	Animals fail to emerge from an egg shell.
WBPhenotype:0000050	embryonic lethal	Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die.
WBPhenotype:0001566	ventral enclosure variant	Any variation in the process that regulates the migration of ventral epidermal cells toward the ventral midline (to encase underlying cells in an epithelial monolayer) in developing embryos compared to control.
WBPhenotype:0000035	larval body morphology variant	Any variation in the overall structure or appearance of the animal as it progresses from hatching to adult compared to control animals.
WBPhenotype:0001478	body elongation variant	Any variation in the elongation of embryonic epidermal cells compared to control. In C. elegans, this elongation occurs along an anterior-posterior axis, which is required to transform the bean-shaped embryo into the elongated shape of the worm.
WBPhenotype:0001395	body vacuole	Vacuoles accumulate in the body. A vacuole is a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material.
WBPhenotype:0000494	two fold arrest	Cessation of development that normally occurs in C. elegans 460-520 min after the first cleavage at 20C, the stage between the 1.5-fold and 3-fold embryo.
WBPhenotype:0001136	embryonic morphology variant	Animals exhibit variations in the form, structure or composition of any of its parts during any developmental stage ranging from zygote formation to hatching compared to control.

0 Phenotype _ Not _ Observed

1 Reference

First Author	Title	Year	Journal	Volume	Pages	PubMed ID
						WBPaper00030774

0 Strain