WormMine: RNAi WBRNAi00094304

• WormBase ID: WBRNAi00094304
• Genotype: bpIs70 [gfp::bro-1(PTC)]
• Phenotype Remark: RNAi resulted in increased larval expression of a gfp::bro-1(PTC) transgene carrying a premature termination codon, indicative of defective mRNA surveillance machinery
• Remark: (Table S1) sknr-1 RNAi

1 Organism

• Name: Caenorhabditis elegans
• Taxon Id: 6239

1 Data Sets

• WormBaseAcedbConverter

1 Inhibits Gene

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00020961	sknr-1	W02H5.7	Caenorhabditis elegans

2 Inhibits Predicted Gene

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:W02H5.7a	W02H5.7a	1158	V: 2622056-2622114
CDS:W02H5.7b	W02H5.7b	522	V: 2622056-2622114

1 Laboratories

Primary Identifier
HZ

3 Phenotype

Identifier	Name	Description
WBPhenotype:0001236	transgene expression increased	Any increase in the intensity of expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to its expression in control animals.
WBPhenotype:0001538	mRNA surveillance defective	Defects in the cellular machinery that targets aberrant mRNAs species (nonsense codons, splice errors, altered untranslated regions etc.) for degradation. In C. elegans, mutations in such loci often act as allele-specific non gene-specific recessive suppressors of certain allele phenotypes and cause abnormal morphogenesis of male and hermaphrodite genitalia.
WBPhenotype:0000508	nonsense mRNA accumulation	Animals exhibit a decrease in the regulated breakdown of mRNA transcripts in which an amino-acid codon has changed to a premature stop codon and the 3 prime end is not protected by a poly(A) tail.

0 Phenotype _ Not _ Observed

1 Reference

First Author	Title	Year	Journal	Volume	Pages	PubMed ID
						WBPaper00040559

0 Strain