WormMine: RNAi WBRNAi00108034

• WormBase ID: WBRNAi00108034
• Genotype: daf-2(e1370)
• Phenotype Remark: "Our RNAi screen was designed to identify serine/threonine phosphatases that modulated dauer formation of daf-2(e1370), a non-null, temperature-sensitive mutant of the C. elegans insulin/ IGF-1 receptor gene, daf-2 [39]. We were particularly interested in phosphatases that would negatively regulate IIS similar to DAF-18/PTEN, and for all RNAi based assays described below, daf-18 RNAi was used as a positive control [39]. From this screen, we identified pdp-1 as a modulator of daf-2(e1370) dauer formation (Figure 1A and Figure S2)... pdp-1 RNAi significantly reduces dauer formation of daf-2(e1370) worms, similar to daf-18 RNAi (Figure 1A and Figure S2)."
• Remark: (Figure 1A,1C,S2A-B, Table 1) pdp-1 RNAi. Exact sequence used for RNAi not stated by authors, Ahringer laboratory clone used for curation.

1 Organism

• Name: Caenorhabditis elegans
• Taxon Id: 6239

1 Data Sets

• WormBaseAcedbConverter

2 Inhibits Gene

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00022832	pdp-1	ZK973.3	Caenorhabditis elegans
WBGene00022834	ZK973.8	ZK973.8	Caenorhabditis elegans

1 Inhibits Predicted Gene

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:ZK973.3	ZK973.3	1356	I: 4368106-4368182

0 Laboratories

1 Phenotype

Identifier	Name	Description
WBPhenotype:0000637	dauer formation variant	Characteristic entry into the dauer stage is altered compared to control animals.

0 Phenotype _ Not _ Observed

1 Reference

First Author	Title	Year	Journal	Volume	Pages	PubMed ID
						WBPaper00038374

0 Strain