WormMine: RNAi WBRNAi00108063

• WormBase ID: WBRNAi00108063
• Genotype: daf-2(e1370); akt-1(ok525)
• Phenotype Remark: "Using dauer formation as the readout, we performed genetic epistasis experiments to identify the substrate of PDP-1. We first tested whether pdp-1 acted directly through the IIS pathway by focusing on kinase mutants downstream of daf-2 (Table 1 and Figure S9). pdk-1(sa680), daf-2(e1370); akt-1(ok525) and daf-2(e1370); akt-2(ok393) mutants were maintained on vector, daf-18 and pdp-1 RNAi and dauer formation of these strains was assayed at the appropriate temperatures. Interestingly, pdp-1 RNAi resulted in suppression of dauer formation of pdk-1(sa680) mutants, daf-2(e1370); akt-1(ok525) and daf-2(e1370); akt-2(ok393) worms (Table 1 and Figure S9)."
• Remark: (Table 1, Figure S9) pdp-1 RNAi. Exact sequence used for RNAi not stated by authors, Ahringer laboratory clone used for curation.

1 Organism

• Name: Caenorhabditis elegans
• Taxon Id: 6239

1 Data Sets

• WormBaseAcedbConverter

2 Inhibits Gene

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00022832	pdp-1	ZK973.3	Caenorhabditis elegans
WBGene00022834	ZK973.8	ZK973.8	Caenorhabditis elegans

1 Inhibits Predicted Gene

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:ZK973.3	ZK973.3	1356	I: 4368106-4368182

0 Laboratories

1 Phenotype

Identifier	Name	Description
WBPhenotype:0000637	dauer formation variant	Characteristic entry into the dauer stage is altered compared to control animals.

0 Phenotype _ Not _ Observed

1 Reference

First Author	Title	Year	Journal	Volume	Pages	PubMed ID
						WBPaper00038374

0 Strain