WormMine: RNAi WBRNAi00087532

• WormBase ID: WBRNAi00087532
• Phenotype Remark: Disrupting par-2 or par-3 function in combination with Galpha had effects on microtubule stability that suggest that PAR proteins affect microtubules independently of G protein signaling: the difference in microtubule stability at the cortex between Galpha(RNAi); par-2(RNAi) and Galpha(RNAi); par-3(RNAi) was on average 15%, similar to the difference in microtubule stability found between embryos where the function of par-2 and par-3 was disrupted individually (p < 0.05). Taken together, these results indicate that Galpha and PAR-3 regulate microtubule dynamics at the cortex, in manners that are at least partially independent.
• Remark: paper remark: Exact sequence used for RNAi not stated by authors, spliced coding region sequence of gene used for curation.

1 Organism

• Name: Caenorhabditis elegans
• Taxon Id: 6239

1 Data Sets

• WormBaseAcedbConverter

3 Inhibits Gene

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00001648	goa-1	C26C6.2	Caenorhabditis elegans
WBGene00001678	gpa-16	Y95B8A.5	Caenorhabditis elegans
WBGene00003917	par-2	F58B6.3	Caenorhabditis elegans

9 Inhibits Predicted Gene

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:C26C6.2	C26C6.2	1065	I: 7522210-7522370
CDS:F58B6.3e	F58B6.3e	486	III: 1091647-1091697
CDS:F58B6.3c	F58B6.3c	228	III: 1094240-1094374
CDS:F58B6.3a	F58B6.3a	1887	III: 1081409-1081519
CDS:F58B6.3b	F58B6.3b	1749	III: 1081409-1081519
CDS:F58B6.3d	F58B6.3d	1746	III: 1081409-1081519
CDS:Y95B8A.5a	Y95B8A.5a	1074	I: 897290-897355
CDS:Y95B8A.5b	Y95B8A.5b	381	I: 903485-903511
CDS:Y95B8A.5c	Y95B8A.5c	348	I: 904617-904844

1 Laboratories

Primary Identifier
LP

1 Phenotype

Identifier	Name	Description
WBPhenotype:0001588	microtubule organization biogenesis variant	Animals exhibit variations in the form, structure, composition or arrangement of a robust macromolecular array, composed primarily of tubulin, which forms long extended cytoskeletal elements compared to control (Wormatlas).

0 Phenotype _ Not _ Observed

1 Reference

First Author	Title	Year	Journal	Volume	Pages	PubMed ID
						WBPaper00005827

0 Strain