WormMine: RNAi WBRNAi00087533

• WormBase ID: WBRNAi00087533
• Phenotype Remark: Disrupting par-2 or par-3 function in combination with Galpha had effects on microtubule stability that suggest that PAR proteins affect microtubules independently of G protein signaling: the difference in microtubule stability at the cortex between Galpha(RNAi); par-2(RNAi) and Galpha(RNAi); par-3(RNAi) was on average 15%, similar to the difference in microtubule stability found between embryos where the function of par-2 and par-3 was disrupted individually (p < 0.05). Taken together, these results indicate that Galpha and PAR-3 regulate microtubule dynamics at the cortex, in manners that are at least partially independent.
• Remark: paper remark: Exact sequence used for RNAi not stated by authors, spliced coding region sequence of gene used for curation.

1 Organism

• Name: Caenorhabditis elegans
• Taxon Id: 6239

1 Data Sets

• WormBaseAcedbConverter

3 Inhibits Gene

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00001648	goa-1	C26C6.2	Caenorhabditis elegans
WBGene00001678	gpa-16	Y95B8A.5	Caenorhabditis elegans
WBGene00003918	par-3	F54E7.3	Caenorhabditis elegans

17 Inhibits Predicted Gene

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:C26C6.2	C26C6.2	1065	I: 7522210-7522370
CDS:F54E7.3j	F54E7.3j	3984	III: 5664372-5664539
CDS:F54E7.3g	F54E7.3g	3903	III: 5668541-5668732
CDS:F54E7.3m	F54E7.3m	3756	III: 5668541-5668732
CDS:F54E7.3l	F54E7.3l	3747	III: 5668541-5668732
CDS:F54E7.3e	F54E7.3e	4356	III: 5668541-5668732
CDS:F54E7.3c	F54E7.3c	4023	III: 5668541-5668861
CDS:F54E7.3d	F54E7.3d	4365	III: 5668541-5668732
CDS:F54E7.3a	F54E7.3a	4131	III: 5664372-5664539
CDS:F54E7.3b	F54E7.3b	4140	III: 5664372-5664539
CDS:F54E7.3f	F54E7.3f	3894	III: 5668541-5668732
CDS:F54E7.3h	F54E7.3h	4593	III: 5664372-5664539
CDS:F54E7.3i	F54E7.3i	4602	III: 5664372-5664539
CDS:F54E7.3k	F54E7.3k	3993	III: 5664372-5664539
CDS:Y95B8A.5a	Y95B8A.5a	1074	I: 897290-897355
CDS:Y95B8A.5b	Y95B8A.5b	381	I: 903485-903511
CDS:Y95B8A.5c	Y95B8A.5c	348	I: 904617-904844

1 Laboratories

Primary Identifier
LP

1 Phenotype

Identifier	Name	Description
WBPhenotype:0001588	microtubule organization biogenesis variant	Animals exhibit variations in the form, structure, composition or arrangement of a robust macromolecular array, composed primarily of tubulin, which forms long extended cytoskeletal elements compared to control (Wormatlas).

0 Phenotype _ Not _ Observed

1 Reference

First Author	Title	Year	Journal	Volume	Pages	PubMed ID
						WBPaper00005827

0 Strain