WormMine

WS294

Intermine data mining platform for C. elegans and related nematodes

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RNAi :

WormBase ID  WBRNAi00092504 Phenotype Remark  mac-1(RNAi) animals complete embryogenesis and hatch, but most stop growing early in the second stage of larval development, and a few arrest later, in the L3 stage; all of these animals continue to move normally. Most of the mac-1(RNAi) animals remain arrested indefinitely, but some slowly continue development and eventually reach adulthood. In addition to this arrest, other defects were observed in mac-1(RNAi) animals. Even in the presence of food, the pharynges of young individuals did not pump normally. After several days, the intestines of most animals had large numbers of vacuoles, and some sections of the intestine were almost completely degraded. Finally, among the mac-1(RNAi) animals that eventually reached adulthood, defects in vulval and gonadal morphogenesis were observed. These defects included the formation of a protruding vulva, and aberrant uterine structure.
Remark  mac-1 RNAi. Exact sequence used for RNAi not stated by authors, spliced coding region sequence of gene used for curation.

1 Organism

Name Taxon Id
Caenorhabditis elegans 6239

1 Data Sets

Name URL
WormBaseAcedbConverter  

1 Inhibits Gene

WormBase Gene ID Gene Name Sequence Name Organism
WBGene00003119 mac-1 Y48C3A.7 Caenorhabditis elegans

1 Inhibits Predicted Gene

WormMine ID Sequence Name Length (nt) Chromosome Location
CDS:Y48C3A.7 Y48C3A.7 2442   II: 13311600-13311749

1 Laboratories

Primary Identifier
RE

8 Phenotype

Identifier Name Description
WBPhenotype:0000697 protruding vulva Animals undergo incomplete vulval morphogenesis, resulting in the formation of a single protrusion at the site of the vulva.
WBPhenotype:0001428 intestinal vacuole Vacuoles accumulate in the intestine.
WBPhenotype:0000691 gonad development variant Variations in the progression of the organ that produces gametes over time, from its formation to the mature structure compared to control.
WBPhenotype:0000699 vulva development variant Variations in the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure compared to control. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult.
WBPhenotype:0000059 larval arrest The developmental program of the animals halts at any larval stage and thus fails to reach adulthood. In C.elegans, this occurs anytime during L1-L4 stage.
WBPhenotype:0000020 pharyngeal pumping irregular Pharyngeal pumping motion occurs at intervals that vary from control animals.
WBPhenotype:0000289 uterus morphology variant Any variation in the form, structure or composition of the portion of the somatic gonad which encloses the fertilized eggs after their passage through the spermatheca compared to control (Wormatlas).
WBPhenotype:0000710 intestinal morphology variant Animals exhibit variations in the form, structure or composition of the chain of cuboidal cells which form a central lumen lined by microvilli that allow the passage of food, compared to control. Food passes from the posterior pharynx to the intestine where it is digested and then on to the rectum which processes the waste products for excretion (Wormatlas).

0 Phenotype _ Not _ Observed

1 Reference

First Author Title Year Journal Volume Pages PubMed ID
            WBPaper00003523

0 Strain