WormMine: RNAi WBRNAi00098312

• WormBase ID: WBRNAi00098312
• Genotype: Pced-1::2xFYVE::GFP (marker for phosphatidylinositol 3-phosphate (PtdIns(3)P) in apoptotic corpse-engulfing cells)
• Phenotype Remark: vps-34(C) RNAi (targeting C-terminal VPS-34) results in a modest accumulation of germ cell corpses, a mild cell-corpse removal defective phenotype, and a reduced percentage of gonadal phagosomes labeled with 2xFYVE::GFP, a marker for phosphatidylinositol 3-phosphate (PtdIns(3)P).
• Remark: (Figure 1A,C, 8E, S1) vps-34(C) RNAi

1 Organism

• Name: Caenorhabditis elegans
• Taxon Id: 6239

1 Data Sets

• WormBaseAcedbConverter

1 Inhibits Gene

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00006932	vps-34	B0025.1	Caenorhabditis elegans

2 Inhibits Predicted Gene

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:B0025.1c	B0025.1c	2694	I: 6028500-6028649
CDS:B0025.1a	B0025.1a	2706	I: 6028488-6028649

1 Laboratories

Primary Identifier
ZH

4 Phenotype

Identifier	Name	Description
WBPhenotype:0000679	transgene subcellular localization variant	Any variation in the subcellular localization of a gene product produced by DNA coded for by exogenous genetic material that has been introduced into the organism compared to its expression in control animals.
WBPhenotype:0000243	engulfment failure by killer cell	Removal of cell corpses through a dedicated engulfment pathway is defective.
WBPhenotype:0001180	accumulated germline cell corpses	Animals exhibit an increase in the quantity of germ line cells that have undergone programmed cell death but have not been engulfed.
WBPhenotype:0001846	phagosome maturation defective	Early phagosomes fail to undergo the maturation process following the ingestion of particulate material by phagocytosis; During maturation, phagosomes acquire markers of late endosomes and lysosomes.

0 Phenotype _ Not _ Observed

1 Reference

First Author	Title	Year	Journal	Volume	Pages	PubMed ID
						WBPaper00040691

0 Strain