WormMine: RNAi WBRNAi00090874

• WormBase ID: WBRNAi00090874
• Genotype: unc-119(ed3) III; cbgIs91[pPept-1:pept-1::DsRed;unc-119(+)]; cbgIs98[pPept-1:GFP::rab-11.1;unc-119(+)]
• Phenotype Remark: PEPT-1::DsRED accumulated in punctate structures; PEPT-1::DsRED accumulated in fuzzy or irregularly shaped structures; PEPT-1::DsRED is retained in RAB-11 recycling endosomes; GFP::RAB-11 recycling endosome (RE) morphology appears diffuse or GFP::RAB-11 is cytosolically distributed; GFP::RAB-11 fluorescence intensity increased; Autofluorescent lysosome-related organelles (AF/LROs) are enlarged or accumulated
• Remark: (Table S1, S3) R06F6.2/vps-11 RNAi

1 Organism

• Name: Caenorhabditis elegans
• Taxon Id: 6239

1 Data Sets

• WormBaseAcedbConverter

1 Inhibits Gene

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00011067	vps-11	R06F6.2	Caenorhabditis elegans

1 Inhibits Predicted Gene

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:R06F6.2	R06F6.2	2943	II: 10788405-10788668

1 Laboratories

Primary Identifier
MZE

5 Phenotype

Identifier	Name	Description
WBPhenotype:0001236	transgene expression increased	Any increase in the intensity of expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to its expression in control animals.
WBPhenotype:0000679	transgene subcellular localization variant	Any variation in the subcellular localization of a gene product produced by DNA coded for by exogenous genetic material that has been introduced into the organism compared to its expression in control animals.
WBPhenotype:0001422	endocytic transport defect	Animals exhibit defects in the directed movement of substances into, out of or mediated by the endosome, a membrane-bound organelle that trafficks material to different compartments of the cell or back to the plasma membrane for recycling.
WBPhenotype:0002094	RAB-11 recycling endosome morphology variant	Any variation in the form or composition of membrane bound organelles, known as recycling endosomes, positive for the RAB protein RAB-11, that traffic material from early endosomes back to the plasma membrane of the cell, thereby recycling recently endocytosed material to be reused at the plasma membrane.
WBPhenotype:0002095	lysosome-related organelle morphology variant	Any variation in the form or composition of membrane bound organelles, known as lysosome-related organelles (LROs) that, like lysosomes, have an acidic interior and generally act to digest components of the cell but are distinct in function, composition, and morphology, compared to control.

0 Phenotype _ Not _ Observed

1 Reference

First Author	Title	Year	Journal	Volume	Pages	PubMed ID
						WBPaper00041129

0 Strain