WormMine: RNAi WBRNAi00106741

• WormBase ID: WBRNAi00106741
• Genotype: pgp-12::GFP
• Phenotype Remark: "Specifically, we injected the dsRNA derived from each gene into the worm expressing a chromosomally integrated marker, that is, pgp-12::GFP, which is exclusively expressed in the excretory cell post-embryonically (Zhao et al, 2005). Examining the morphological defects in excretory canals revealed that all of the surviving L1 larvae showed various defects in the excretory canals (Supplementary Fig S9I-P). RNAi against snfc-5 also produced an extra nucleus, suggesting a defect in fate specification of the excretory cell. RNAi against tbx-33 and ceh-43 produced canals with a 'thorn'-like protrusion. Inactivation of let-526 and arx-1 led to incomplete canals while that of sptf-3 seemed to affect tube morphogenesis. RNAi against most of these genes (i.e sptf-3) induced a high penetrance of embryonic lethality. Therefore, the morphological changes in the excretory canal should be treated as a hypomorphic rather than a null phenotype."
• Remark: (Figure S9) ceh-43 RNAi

1 Organism

• Name: Caenorhabditis elegans
• Taxon Id: 6239

1 Data Sets

• WormBaseAcedbConverter

1 Inhibits Gene

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00000463	ceh-43	C28A5.4	Caenorhabditis elegans

2 Inhibits Predicted Gene

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:C28A5.4a	C28A5.4a	822	III: 4446843-4447016
CDS:C28A5.4b	C28A5.4b	849	III: 4446843-4447016

0 Laboratories

1 Phenotype

Identifier	Name	Description
WBPhenotype:0000704	excretory canal morphology variant	Variations in the form or composition of structures made by the processes of the excretory canal cell compared to control (Wormatlas).

0 Phenotype _ Not _ Observed

1 Reference

First Author	Title	Year	Journal	Volume	Pages	PubMed ID
						WBPaper00046953

0 Strain