WormMine: RNAi WBRNAi00097135

• WormBase ID: WBRNAi00097135
• Phenotype Remark: bir-1 RNAi embryos were multinucleate and over 75% of embryos failed to form more than two cells. Whereas cytokinesis initiated normally, and the cleavage furrow progressed to a great extent, cytokinesis failed to complete and the cleavage furrow subsequently regressed. Following the regression of the cleavage furrow, the nuclei entered a new cell cycle, resulting in highly multinucleate zygotes. The bir-1(RNAi) embryos were also defective in the extrusion of the polar body.
• Remark: (Figure 5) bir-1 RNAi. Exact sequence used for RNAi not stated by authors, spliced coding region sequence of gene used for curation.

1 Organism

• Name: Caenorhabditis elegans
• Taxon Id: 6239

1 Data Sets

• WormBaseAcedbConverter

1 Inhibits Gene

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00000249	bir-1	T27F2.3	Caenorhabditis elegans

1 Inhibits Predicted Gene

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:T27F2.3	T27F2.3	468	V: 11644763-11644885

1 Laboratories

Primary Identifier
WS

5 Phenotype

Identifier	Name	Description
WBPhenotype:0000867	embryonic arrest	Cessation of development during any stage occurring after fertilization and until hatching compared to control.
WBPhenotype:0000777	polar body extrusion defective early emb	Unextruded or resorbed polar body(ies) leading to an extra PNs in P0 and/or extra karyomeres in AB/P1.
WBPhenotype:0001078	cytokinesis defective early emb	Cytokinesis is abnormal in the first or second stages of cell division.
WBPhenotype:0001143	multiple nuclei early emb	Embryos contain more than one nucleus per cell in the inviable one- to four-cell embryo.
WBPhenotype:0001886	cleavage furrow termination defective early emb	Embryos exhibit defects in the maintenance or termination of the groove in the cell surface near the old metaphase plate during cytokinesis.

0 Phenotype _ Not _ Observed

1 Reference

First Author	Title	Year	Journal	Volume	Pages	PubMed ID
						WBPaper00003470

0 Strain