WormMine: RNAi WBRNAi00092399

• WormBase ID: WBRNAi00092399
• Phenotype Remark: mes-4 RNAi resulted in a loss of H3K36me3 (histone 3 lysine 36 trimethylation) and acquisition of H3K27me3 (histone 3 lysine 27 trimethylation) on genes with germline-specific expression. Alternatively, mes-4 RNAi resulted in an overall decrease in H3K27me3 of genes on the X chromosome. These genes were enriched for ubiquitously expressed and soma-specific genes. Of autosomal genes that underwent a decrease of H3K27me3, there was an enrichment for soma-specific genes. Of autosomal genes that underwent an increase of H3K27me3, there was an enrichment for ubiquitous, germline-enriched, and germline-specific genes.
• Remark: (Figure 3B, 3C, 4C) mes-4 RNAi

1 Organism

• Name: Caenorhabditis elegans
• Taxon Id: 6239

1 Data Sets

• WormBaseAcedbConverter

1 Inhibits Gene

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00003222	mes-4	Y2H9A.1	Caenorhabditis elegans

1 Inhibits Predicted Gene

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:Y2H9A.1	Y2H9A.1	2697	V: 13433442-13433681

1 Laboratories

Primary Identifier
SS

1 Phenotype

Identifier	Name	Description
WBPhenotype:0002078	histone methylation variant	The pattern or state of methyl modifications of histone varies from that of controls.

0 Phenotype _ Not _ Observed

1 Reference

First Author	Title	Year	Journal	Volume	Pages	PubMed ID
						WBPaper00041688

1 Strain

WormBase ID
WBStrain00000001