RNAi was observed to significantly reduce cytosolic protein levels in body wall muscles, as determined by reduced LacZ staining compared to controls. This affect was observed after chronic RNAi exposure (RNAi continuously for two generations), but not after acute exposure to RNAi only during adulthood.
Variations in the chemical reactions and pathways resulting in the directed breakdown of a protein (via the destruction of its native, active configuration) compared to control.