The daf-18(e1375) mutation failed to suppress the RNAi-induced increase in muscle protein degradation, as determined by LacZ staining, suggesting that this increase in degradation is not dependent on the daf-18 gene or the Insulin-like signaling pathway, of which daf-18 is a part.
Variations in the chemical reactions and pathways resulting in the directed breakdown of a protein (via the destruction of its native, active configuration) compared to control.