WormMine: RNAi WBRNAi00108046

• WormBase ID: WBRNAi00108046
• Genotype: daf-2(e1370)
• Phenotype Remark: "We therefore investigated whether dosage modulation of pdp-1 would affect additional outputs of the pathway. We first tested the role of PDP-1 in regulating lifespan (Figure 2 and Figure S4). The lifespan of wild-type worms was not affected by pdp-1 RNAi and slightly reduced by a mutation in pdp-1 (Figure 2A and 2D). In contrast, the mean and maximal lifespan of long-lived daf-2(e1370) and age-1(hx546) mutants was significantly reduced by pdp-1 RNAi (Figure 2B and 2C)."
• Remark: (Figure 2B,S4B) pdp-1 RNAi. Exact sequence used for RNAi not stated by authors, Ahringer laboratory clone used for curation.

1 Organism

• Name: Caenorhabditis elegans
• Taxon Id: 6239

1 Data Sets

• WormBaseAcedbConverter

2 Inhibits Gene

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00022832	pdp-1	ZK973.3	Caenorhabditis elegans
WBGene00022834	ZK973.8	ZK973.8	Caenorhabditis elegans

1 Inhibits Predicted Gene

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:ZK973.3	ZK973.3	1356	I: 4368106-4368182

0 Laboratories

1 Phenotype

Identifier	Name	Description
WBPhenotype:0001171	shortened life span	The duration of viability in the adult phase of the life-cycle is less than that of control animals.

0 Phenotype _ Not _ Observed

1 Reference

First Author	Title	Year	Journal	Volume	Pages	PubMed ID
						WBPaper00038374

0 Strain