WormMine: RNAi WBRNAi00110239

• WormBase ID: WBRNAi00110239
• Genotype: zcIs13 [hsp-6p::GFP]; rmIs101 [rgef-1p::Q40::YFP]
• Phenotype Remark: "We predicted that the cell-non-autonomous induction of mitochondrial chaperones observed with neuronal polyQ40 expression requires one or more essential UPRmt factors. To test this hypothesis, we applied RNAi against ubl-5, dve-1, atfs-1, and clpp-1, and cco-1 to neuronal polyQ40 worms expressing hsp-6p::GFP. RNAi against dve-1, atfs-1, and clpp-1 blocked the induction of the hsp-6p::GFP reporter in peripheral tissues, while cco-1 RNAi showed robust induction (Figures 2A and 2B)."
• Remark: (Figure 2A, 2B) clpp-1 RNAi. Exact sequence used for RNAi not stated by authors, Ahringer laboratory clone used for curation.

1 Organism

• Name: Caenorhabditis elegans
• Taxon Id: 6239

1 Data Sets

• WormBaseAcedbConverter

6 Inhibits Gene

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00007022	mdt-22	ZK970.3	Caenorhabditis elegans
WBGene00014172	clpp-1	ZK970.2	Caenorhabditis elegans
WBGene00014638	ZK970.t4	ZK970.t4	Caenorhabditis elegans
WBGene00014635	ZK970.t1	ZK970.t1	Caenorhabditis elegans
WBGene00014637	ZK970.t3	ZK970.t3	Caenorhabditis elegans
WBGene00014636	ZK970.t2	ZK970.t2	Caenorhabditis elegans

4 Inhibits Predicted Gene

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:ZK970.2a	ZK970.2a	621	II: 10300824-10300934
CDS:ZK970.3	ZK970.3	474	II: 10301247-10301321
CDS:ZK970.2b	ZK970.2b	354	II: 10300824-10300934
CDS:ZK970.2d	ZK970.2d	666	II: 10300824-10300934

0 Laboratories

1 Phenotype

Identifier	Name	Description
WBPhenotype:0001278	transgene expression reduced	Any decrease in the intensity of expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to its expression in control animals.

0 Phenotype _ Not _ Observed

1 Reference

First Author	Title	Year	Journal	Volume	Pages	PubMed ID
						WBPaper00050142

0 Strain