WormMine

WS295

Intermine data mining platform for C. elegans and related nematodes

Gene :

WormBase Gene ID  ? WBGene00003366 Gene Name  mir-273
Sequence Name  ? E01F3.2 Brief Description  mir-273 encodes a microRNA, a small non-protein coding RNA; miR-273 is involved in the pathway for functional lateralization of the chemosensory ASE neuron; miR-273 regulates the spatial expression of another miRNA, lsy-6, repressing lsy-6 expression in the ASER neuron; this regulation is mediated by the DIE-1 zinc-finger transcription factor; mir-273 is expressed in several bilaterally symmetric pairs of head neurons, including ASE neurons, with expression in ASER being significantly higher than ASEL.
Organism  Caenorhabditis elegans Automated Description  Enables mRNA regulatory element binding translation repressor activity. Involved in asymmetric protein localization involved in cell fate determination; miRNA-mediated post-transcriptional gene silencing; and neuroblast fate determination. Expressed in ASEL and ASER.
Biotype  SO:0001265 Genetic Position  II :23.7723 ±0.010703
Length (nt)  ? 94
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1 Organism

Name Taxon Id
Caenorhabditis elegans 6239

1 Synonyms

Value
WBGene00003366

Genomics

1 Transcripts

WormMine ID Sequence Name Length (nt) Chromosome Location
Transcript:E01F3.2b E01F3.2b 20   II: 14947097-14947116
 

Other

0 CDSs

0 RNAi Result

9 Allele

Public Name
gk963801
gk963053
gk962684
gk963297
h5529
WBVar00557512
WBVar00019773
n4438
tm2274

1 Chromosome

WormBase ID Organism Length (nt)
II Caenorhabditis elegans 15279421  

1 Chromosome Location


Feature . Primary Identifier
Start End Strand
WBGene00003366 14947039 14947132 1

3 Data Sets

Name URL
WormBaseAcedbConverter  
GO Annotation data set  
C. elegans genomic annotations (GFF3 Gene)  

0 Downstream Intergenic Region

2 Expression Clusters

Regulated By Treatment Description Algorithm Primary Identifier
  Neuronally enriched transcripts according to a comparison of neuronal nuclei IP samples to total nuclei using isolation of nuclei from tagged specific cell types (INTACT) technology. DESEQ2, fold change > 2 and FDR < 0.01. WBPaper00062103:neuron_enriched
  micro RNAs that exhibit changes in expression during adulthood (p-value < = 0.05). Authors searched for targets with seed matches of perfect Watson-Crick base-pair complementarity to positions two-eight of the miRNAs (counting from the 5' end). In order to consider these seed matches as potential target sites, authors required a minimal cut-off for binding specificity of the remainder of the miRNA to the target. Recent evidence suggests that this is not required for function in humans, but 3' binding does occur in studies of C. elegans. Authors used the scoring algorithm from Robins et al. (2005). The binding cut-off is determined by creating a second-order Markov model of the background for the 3' UTRs. The cut off was p-value < = 0.05. WBPaper00028344:adult_expr_change

1 Expression Patterns

Remark Reporter Gene Primary Identifier Pattern Subcellular Localization
No detailed description on cellular expression pattern in other tissue or life stage.   Expr4409 50% of animals have more expression in ASHL than in ASHR, about 40% of animals have equal expression in ASHL and ASHR.  

5 GO Annotation

Annotation Extension Qualifier
  involved_in
  involved_in
  involved_in
  enables
  enables

0 Homologues

1 Locations


Feature . Primary Identifier
Start End Strand
WBGene00003366 14947039 14947132 1

5 Ontology Annotations

Annotation Extension Qualifier
  involved_in
  involved_in
  involved_in
  enables
  enables

0 Regulates Expr Cluster

1 Sequence

Length
94

1 Sequence Ontology Term

Identifier Name Description
gene  

1 Strains

WormBase ID
WBStrain00027453

0 Upstream Intergenic Region