Predicted to enable NAD+ nucleosidase activity and signaling adaptor activity. Predicted to be involved in negative regulation of MyD88-independent toll-like receptor signaling pathway; response to axon injury; and signal transduction. Is an ortholog of C. elegans tir-1. In C. elegans, tir-1 is involved in several processes, including NAD catabolic process; defense response to other organism; and regulation of gene expression.