WormMine: Gene WBGene00225693

• WormBase Gene ID: WBGene00225693
• Gene Name: Bma-dpy-31
• Sequence Name: Bm5432
• Organism: Brugia malayi
• Automated Description: Predicted to enable metalloendopeptidase activity and zinc ion binding activity. Predicted to be involved in molting cycle and proteolysis. Expressed in excretory duct; intestine; and pharyngeal gland cell. Is an ortholog of C. elegans dpy-31. In C. elegans, dpy-31 is involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle.
• Biotype: SO:0001217
• Genetic Position: :±

1 Organism

• Name: Brugia malayi
• Taxon Id: 6279

0 Synonyms

Genomics

2 Transcripts

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
Transcript:Bm5432b.1	Bm5432b.1		[unknown]
Transcript:Bm5432a.1	Bm5432a.1		[unknown]

Other

2 CDSs

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:Bm5432a	Bm5432a		[unknown]
CDS:Bm5432b	Bm5432b		[unknown]

0 RNAi Result

0 Allele

0 Chromosome

0 Chromosome Location

2 Data Sets

• WormBaseAcedbConverter
• GO Annotation data set

0 Downstream Intergenic Region

7 Expression Clusters

Regulated By Treatment	Description	Algorithm	Primary Identifier
	Transcripts that showed significantly decreased expression in male B. malayi 120 days after infecting gerbils, comparing to female B. malayi 120 days after infecting gerbils.	EdgeR(v3.16.5), FDR < 0.05.	WBPaper00051007:downregulated_M120_vs_F120
	Transcripts that showed significantly increased expression in male B. malayi 120 days after infecting gerbils, comparing to 30 days after infecting gerbils.	EdgeR(v3.16.5), FDR < 0.05.	WBPaper00051007:upregulated_M120_vs_M30
	Transcripts that showed significantly decreased expression in male B. malayi 42 days after infecting gerbils, comparing to 30 days after infecting gerbils.	EdgeR(v3.16.5), FDR < 0.05.	WBPaper00051007:downregulated_M42_vs_M30
	Transcripts that showed significantly increased expression in male B. malayi 120 days after infecting gerbils, comparing to 42 days after infecting gerbils.	EdgeR(v3.16.5), FDR < 0.05.	WBPaper00051007:upregulated_M120_vs_M42
	Transcripts that showed significantly increased expression in male B. malayi 30 days after infecting gerbils, comparing to female B. malayi 30 days after infecting gerbils.	EdgeR(v3.16.5), FDR < 0.05.	WBPaper00051007:upregulated_M30_vs_F30
	Transcripts that showed significantly increased expression in male B. malayi 30 days after infecting gerbils, comparing to L4 male B. malayi animals.	EdgeR(v3.16.5), FDR < 0.05.	WBPaper00051007:upregulated_M30_vs_L4
	Time-course transcript abundance profiles. P116, k-means clusters of Brugia malayi during development in Aedes aegypti LVP between day 1 and 8 post infection; H114, k-means clusters of Ae. aegypti LVP infected with B. malayi between day 0 and 8 post infection; and HR14, host response profile comparing infected vs. uninfected A. aegypti LVP.	Non-flat profiles (p < 0.01 and maximum fold-difference among time points > 2) were grouped into common temporal patterns using k-means clustering.	WBPaper00045439:BM_Cluster_P9

2 Expression Patterns

• Primary Identifier: Expr12862
• Pattern: Expression of B. malayi DPY-31 is predominantly restricted to the gut cells of C. elegans. This expression pattern was consistent throughout all life-cycle stages, including embryos, larvae and adults. B. malayi dpy-31 promoter/reporter was also expressed in the gland cells of the pharynx.

• Primary Identifier: Expr12863
• Pattern: The C. elegans N2 strain was also examined for the expression of DPY-31 following immunolocalisation with a C. elegans affinity purified anti-DPY- 31 peptide antibody. As for the transgenic reporter fusion (Expr12862), the expression of CeDPY-31 was primarily located in the gut cells, but was also found in the excretory duct of the excretory system.

5 GO Annotation

0 Homologues

0 Locations

5 Ontology Annotations

0 Regulates Expr Cluster

0 Sequence

1 Sequence Ontology Term

• Name: gene

0 Strains

0 Upstream Intergenic Region