WormMine: Gene WBGene00235325

• WormBase Gene ID: WBGene00235325
• Gene Name: C08D8.7
• Sequence Name: C08D8.7
• Organism: Caenorhabditis elegans
• Automated Description: Predicted to be located in membrane.
• Biotype: SO:0001217
• Genetic Position: :±
• Length (nt): 4306

1 Organism

• Name: Caenorhabditis elegans
• Taxon Id: 6239

1 Synonyms

• Value: WBGene00235325

Genomics

2 Transcripts

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
Transcript:C08D8.7.2	C08D8.7.2	3256	V: 8341224-8345529
Transcript:C08D8.7.1	C08D8.7.1	696	V: 8343769-8345514

Other

1 CDSs

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:C08D8.7	C08D8.7	267	V: 8344018-8344232

0 RNAi Result

41 Allele

• gk963301
• WBVar02060334
• WBVar02060335
• gk964351
• gk962860
• WBVar01862986
• WBVar01862985
• WBVar01862988
• WBVar01862987
• gk964293
• gk241234
• gk241235
• gk241236
• gk241237
• gk241238
• gk948629
• gk948628
• ttTi15073
• WBVar01678072
• gk331830
• gk546770
• gk450664
• gk695535
• gk905666
• gk834550
• gk843005
• gk922572
• gk392036
• gk597903
• gk585752

1 Chromosome

• WormBase ID: V
• Organism: Caenorhabditis elegans
• Length (nt): 20924180

1 Chromosome Location

• Feature . Primary Identifier: WBGene00235325
• Start: 8341224
• End: 8345529
• Strand: 1

3 Data Sets

• WormBaseAcedbConverter
• GO Annotation data set
• C. elegans genomic annotations (GFF3 Gene)

1 Downstream Intergenic Region

• WormBase ID: intergenic_region_chrV_8345530..8345758
• Length (nt): 229
• Chromosome Location: V: 8345530-8345758
• Organism: Caenorhabditis elegans

43 Expression Clusters

Regulated By Treatment	Description	Algorithm	Primary Identifier
	Transcripts that showed significantly increased expression in L1 neural cells comparing to in adult neural cells.	DESeq2 (v1.18.1) fold change > 2, P-adj<0.05, using BenjaminiHochberg correction.	WBPaper00060811:L1_vs_adult_upregulated_neural
	Transcripts of coding genes that showed significantly decreased expression in muscle.	DESeq2 (version 1.24.0). Transcripts with a false-discovery rate adjusted p-value less than 0.05 were considered significantly differentially expressed.	WBPaper00062325:muscle_depleted_coding-RNA
	Neuronally enriched transcripts according to a comparison of neuronal nuclei IP samples to total nuclei using isolation of nuclei from tagged specific cell types (INTACT) technology.	DESEQ2, fold change > 2 and FDR < 0.01.	WBPaper00062103:neuron_enriched
	Transcripts expressed in intestine, according to PAT-Seq analysis using Pges-1-GFP-3XFLAG mRNA tagging.	Cufflinks FPKM value >=1.	WBPaper00050990:intestine_expressed
	Transcripts that showed significantly decreased expression in tetraploid N2 comparing to diploid N2 animals at L4 larva stage.	DESeq2 R package (1.20.0), fold change > 2, and FDR < 0.05.	WBPaper00066110:tetraploid_vs_diploid_downregulated
	Transcripts that showed significantly increased expression in ilc-17.1(syb5296) comparing to in N2 animals at L4 larva stage.	DESeq2, fold change > 2, FDR < 0.05.	WBPaper00066594:ilc-17.1(syb5296)_upregulated
	Transcripts that showed significantly increased expression at 5-days-post L4 adult N2 hermaphrodites comparing to 1-day-post L4 adult N2 hermaphrodites.	DESeq2, fold change > 2, FDR < 0.05	WBPaper00065835:Day5_vs_Day1_upregulated
	Transcripts unqiuely expressed in intestine, according to PAT-Seq analysis using Pges-1-GFP-3XFLAG mRNA tagging.	Cufflinks FPKM value >=1.	WBPaper00050990:intestine_enriched
Bacteria diet: complex environmental microbiotas	Transcripts that showed significantly decreased expression after L1 larva grew on soil microbiota at 25C for 3 days.	N.A.	WBPaper00056139:soil-microbiota_downregulated
	Transcripts that showed significantly increased expression in N2 animals exposed to 0.1mM Paraquat from hatching to reaching adult stage.	DESeq2 version 1.22.2, p < 0.05	WBPaper00064716:paraquat_upregulated
	Transcripts that showed significantly decreased expression glp-1(e2141); TU3401 animals comparing to in TU3401 animals.	Fold change > 2, FDR < 0.01.	WBPaper00065993:glp-1(e2141)_downregulated
	Transcripts that showed significantly increased expression in mrps-5(RNAi) animals comparing to animals injected with empty vector.	Differential expression was assessed using a Partial least-squares discriminant analysis (PLS-DA) using mixomics setting a variable of importance (VIP) score of greater than 1 as significant.	WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
	Transcripts that showed significantly increased expression 2 hours after auxin-induced MOG-7-degron to remove endogenous MOG-7 protein.	N.A.	WBPaper00062146:MOG-7-degron_2h_regulated
	Single-cell RNA-Seq cell group 74_0 expressed in neuron.	scVI 0.6.0	WBPaper00065841:74_0
	Transcripts that showed significantly decreased expression in daf-16(mu86);daf-2(e1370) neurons comparing to in daf-2(e1370) neurons at day 8adult stage.	DESeq2, FDR < 0.05, fold change > 2.	WBPaper00066978:daf-16(mu86)_downregulated_neuron
Temperature shift: 15C vs 20 C.	Transcripts that showed significantly decreased expression in N2 animals treated with empty RNAi vector at 15C comparing to N2 animals treated with empty RNAi vector at 20C.	Statistical comparisons were made by two-tailed t-test, n=3 (each replicate contains 150 extruded germ lines from N2 wild-type worms), P < 0.01 was considered significant.	WBPaper00057288:Cold_downregulated_transcript
	Transcripts enriched in purified oocyte P bodies comparing to in the whole animal.	DESeq2, FDR < 0.05, fold change > 2.	WBPaper00065975:P-body_vs_WholeAnimal_enriched
	Transcripts that showed significantly decreased expression in swsn-1(os22ts) comparing to in N2 animals at young adult worms.	DESeq2, FDR<0.05 and fold-change 2. (Threshold set by WormBase curator.)	WBPaper00060764:swsn-1(os22ts)_downregulated
	Transcripts that showed significantly decreased expression in unc-30(ok613) animals at L4 larva stage after 4 hours of Pseudomonas aeruginosa infection, comparing to infected N2 animals.	Genes exhibiting at least two-fold change were considered differentially expressed.	WBPaper00061439:unc-30(ok613)_downregulated_P.aeruginosa-infection
	Top 300 transcripts enriched in RIAL, RIAR according to single cell RNAseq.	Top 300 enriched transcripts were determined by log2.ratio of the tpm in the cell type vs the tpm in the other cells * the log2 of the cell.type tpm.	WBPaper00061340:RIA
	Transcripts that showed significantly increased expression in ins-11(tm1053) young adult animals comparing to in N2.	For log2 fold changes > 0.00001 the values > 81.25th percentile were defined as up-regulated and for log2 fold changes < -0.00001 the values < 18. 75th percentile were defined as down-regulated.	WBPaper00053664:ins-11(tm1053)_upregulated
	Top 300 transcripts enriched in AVKL, AVKR according to single cell RNAseq.	Top 300 enriched transcripts were determined by log2.ratio of the tpm in the cell type vs the tpm in the other cells * the log2 of the cell.type tpm.	WBPaper00061340:AVK
	Transcripts significantly enriched in AVK neurons comparing to all cell types at L1 larva stage.	edgeR, FDR < 0.001, fold change > 2.	WBPaper00055565:AVK_enriched
	Transcripts that showed significantly increased expression in AFD neuron cells comparing to in whole animal, according to dissected single neuron RNASeq analysis.	Fold change >= 4.	WBPaper00050344:AFD-neuron_enriched
	Single-cell RNA-Seq cell group 85_0 expressed in neuron.	scVI 0.6.0	WBPaper00065841:85_0
	Transcripts that showed significantly increased expression in pfd-6(gk493446); daf-2(e1370) comparing to in daf-2(e1370).	Limma version 3.24.15. Fold change < 0.67 (p < 0.05).	WBPaper00055827:pfd-6(gk493446)_upregulated
	Single-cell RNA-Seq cell group 75_0 expressed in neuron.	scVI 0.6.0	WBPaper00065841:75_0
	Top 300 transcripts enriched in OLLL, OLLR according to single cell RNAseq.	Top 300 enriched transcripts were determined by log2.ratio of the tpm in the cell type vs the tpm in the other cells * the log2 of the cell.type tpm.	WBPaper00061340:OLL
	Single-cell RNA-Seq cell group 28_0 expressed in neuron.	scVI 0.6.0	WBPaper00065841:28_0
	Transcripts that showed significantly increased expression in ASER neuron cells comparing to in whole animal, according to dissected single neuron RNASeq analysis.	Fold change >= 4.	WBPaper00050344:ASER-neuron_enriched

2 Expression Patterns

• Primary Identifier: Expr2000603
• Pattern: Single cell embryonic expression. Only cell types with an expression fraction of greater 0.2 of the maximum expressed fraction are labeled (Full data can be downloaded from http://caltech.wormbase.org/pub/wormbase/datasets-published/packer2019/). The colors represent the broad cell class to which the cell type has been assigned. The size of the point is proportional to the log2 of the numbers of cells in the dataset of that cell type. Interactive visualizations are available as a web app (https://cello.shinyapps.io/celegans/) and can also be installed as an R package (https://github.com/qinzhu/VisCello.celegans).

• Primary Identifier: Expr2018830
• Pattern: Single cell embryonic expression. Only cell types with an expression fraction of greater 0.2 of the maximum expressed fraction are labeled (Full data can be downloaded from http://caltech.wormbase.org/pub/wormbase/datasets-published/packer2019/). The colors represent the broad cell class to which the cell type has been assigned. The size of the point is proportional to the log2 of the numbers of cells in the dataset of that cell type. Interactive visualizations are available as a web app (https://cello.shinyapps.io/celegans/) and can also be installed as an R package (https://github.com/qinzhu/VisCello.celegans).

1 GO Annotation

0 Homologues

1 Locations

• Feature . Primary Identifier: WBGene00235325
• Start: 8341224
• End: 8345529
• Strand: 1

1 Ontology Annotations

0 Regulates Expr Cluster

1 Sequence

• Length: 4306

1 Sequence Ontology Term

• Name: gene

0 Strains

1 Upstream Intergenic Region

• WormBase ID: intergenic_region_chrV_8340757..8341223
• Length (nt): 467
• Chromosome Location: V: 8340757-8341223
• Organism: Caenorhabditis elegans