WormMine: Gene WBGene00000289

• WormBase Gene ID: WBGene00000289
• Gene Name: cam-1
• Sequence Name: C01G6.8
• Brief Description: cam-1 encodes a receptor tyrosine kinase of the immunoglobulin superfamily that is orthologous to human ROR1 (OMIM:602336) and ROR2 (OMIM:602337, mutation of which leads to type B brachydactyly); cam-1 is required for locomotion, cell migration, asymmetric cell division, axon outgrowth, and dauer formation; CAM-1, along with LIN-17, CWN-2, and DSH-1, functions as part of a Wnt signaling pathway that regulates ACR-16 localization to postsynaptic regions, a key component of activity-dependent synaptic plasticity; CAM-1 is broadly expressed during embryogenesis and larval development with expression first appearing at the 200-cell stage of embryogenesis; in muscle arms, CAM-1 colocalizes with LIN-17.
• Organism: Caenorhabditis elegans
• Automated Description: Enables Wnt-protein binding activity; frizzled binding activity; and transmembrane receptor protein tyrosine kinase activity. Involved in generation of neurons and neuroblast migration. Located in axon; neuromuscular junction; and somatodendritic compartment. Expressed in several structures, including QL.aa; head; neurons; pharynx; and seam cell. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive Robinow syndrome; autosomal recessive nonsyndromic deafness 108; and brachydactyly type B1. Is an ortholog of human ROR1 (receptor tyrosine kinase like orphan receptor 1).
• Biotype: SO:0001217
• Genetic Position: II :1.10355 ±0.006145
• Length (nt): 14390

1 Organism

• Name: Caenorhabditis elegans
• Taxon Id: 6239

1 Synonyms

• Value: WBGene00000289

Genomics

4 Transcripts

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
Transcript:C01G6.8c.1	C01G6.8c.1	2907	II: 9295915-9299323
Transcript:C01G6.8b.1	C01G6.8b.1	3232	II: 9295918-9304853
Transcript:C01G6.8a.1	C01G6.8a.1	3281	II: 9295918-9310304
Transcript:C01G6.8c.2	C01G6.8c.2	2796	II: 9295928-9298978

Other

3 CDSs

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:C01G6.8c	C01G6.8c	2310	II: 9296409-9296551
CDS:C01G6.8a	C01G6.8a	2787	II: 9296409-9296551
CDS:C01G6.8b	C01G6.8b	2709	II: 9296409-9296551

19 RNAi Result

• WBRNAi00102161
• WBRNAi00039359
• WBRNAi00024437
• WBRNAi00008321
• WBRNAi00008574
• WBRNAi00098201
• WBRNAi00028308
• WBRNAi00097964
• WBRNAi00061666
• WBRNAi00060177
• WBRNAi00060178
• WBRNAi00060179
• WBRNAi00060180
• WBRNAi00066758
• WBRNAi00086121
• WBRNAi00077185
• WBRNAi00099025
• WBRNAi00099027
• WBRNAi00099026

201 Allele

• gk963801
• gk963053
• gk962682
• gk962798
• WBVar00240364
• WBVar00240698
• otn11989
• otn11991
• otn11990
• sa692
• WBVar01696113
• WBVar01696114
• WBVar01696115
• WBVar01604435
• WBVar01604434
• WBVar01439045
• WBVar01821065
• WBVar01546700
• h8911
• h3299
• h15125
• h4936
• cxTi5812
• gk942063
• WBVar01720469
• WBVar01902596
• snx2288
• WBVar01784348
• WBVar01784349
• xd13

1 Chromosome

• WormBase ID: II
• Organism: Caenorhabditis elegans
• Length (nt): 15279421

1 Chromosome Location

• Feature . Primary Identifier: WBGene00000289
• Start: 9295915
• End: 9310304
• Strand: -1

4 Data Sets

• WormBaseAcedbConverter
• GO Annotation data set
• C. elegans genomic annotations (GFF3 Gene)
• Panther orthologue and paralogue predictions

1 Downstream Intergenic Region

• WormBase ID: intergenic_region_chrII_9295819..9295914
• Length (nt): 96
• Chromosome Location: II: 9295819-9295914
• Organism: Caenorhabditis elegans

176 Expression Clusters

Regulated By Treatment	Description	Algorithm	Primary Identifier
	Genes with expression altered >= 3-fold in dpy-10(e128) mutants.	Data across the wild type series was analyzed using the Significance analysis of Microarrays (SAM) algorithm (to calculate the False Discovery Rate (FDR)).	WBPaper00035873:dpy-10_regulated
	Transcripts that showed significantly increased expression in L1 neural cells comparing to in adult neural cells.	DESeq2 (v1.18.1) fold change > 2, P-adj<0.05, using BenjaminiHochberg correction.	WBPaper00060811:L1_vs_adult_upregulated_neural
	Transcripts expressed in neuronal cells, by analyzingfluorescence-activated cell sorted (FACS) neurons.	DESeq. False discovry rate (FDR) < 0.1.	WBPaper00048988:neuron_expressed
	Genes that showed expression levels higher than the corresponding reference sample (embryonic 24hr reference).	A Mann-Whitney U test with an empirical background model and FDR correction for multiple testing was used to detect expressed transcripts (Benjamini and Hochberg 1995). Genes and TARs with an FDR <= 0.05 were reported as expressed above background. Authors detected differentially expressed transcripts using a method based on linear models. Genes and TARs were called differentially expressed if the FDR was <= 0.05 and the fold change (FC) >= 2.0. To more strictly correct for potential false-positives resulting from multiple sample comparisons, authors divided individual FDR estimates by the number of samplesor sample comparisons, respectively. This resulted in an adjusted FDR of 1.3 * 0.0001 for expression above background and of 7.4 * 0.0001 for differential expression. Authors called genes selectively enriched in a given tissue if they met the following requirements: (1) enriched expression in a given tissue (FDR <= 0.05 and FC >= 2.0), (2) fold change versus reference among the upper 40% of the positive FC range observed for this gene across all tissues, and (3) fold-change entropy among the lower 40% of the distribution observed for all genes.	WBPaper00037950:all-neurons_L1-larva_expressed
adult vs dauer larva	Transcripts that showed differential expression in adult vs dauer lava in N2 animals at 20C.	N.A.	WBPaper00050488:adult_vs_dauer_regulated_N2_20C
	mRNAs that showed decreased expression in 1 cell mebryo comparing to in oocyte, according to RNAseq analysis.	Gaussian error propagation. As cutoff for the up-regulated genes authors used log2 fold change > 1 and P < 0.05 and as cutoff for the down-regulated genes authors used log2 fold change < -1 and P < 0.05.	WBPaper00045420:fertilization_downregulated_transcript
	Genes that showed expression levels higher than the corresponding reference sample (embryonic 24hr reference).	A Mann-Whitney U test with an empirical background model and FDR correction for multiple testing was used to detect expressed transcripts (Benjamini and Hochberg 1995). Genes and TARs with an FDR <= 0.05 were reported as expressed above background. Authors detected differentially expressed transcripts using a method based on linear models. Genes and TARs were called differentially expressed if the FDR was <= 0.05 and the fold change (FC) >= 2.0. To more strictly correct for potential false-positives resulting from multiple sample comparisons, authors divided individual FDR estimates by the number of samplesor sample comparisons, respectively. This resulted in an adjusted FDR of 1.3 * 0.0001 for expression above background and of 7.4 * 0.0001 for differential expression. Authors called genes selectively enriched in a given tissue if they met the following requirements: (1) enriched expression in a given tissue (FDR <= 0.05 and FC >= 2.0), (2) fold change versus reference among the upper 40% of the positive FC range observed for this gene across all tissues, and (3) fold-change entropy among the lower 40% of the distribution observed for all genes.	WBPaper00037950:AVE-neuron_L1-larva_expressed
Osmotic stress	Transcripts that showed significantly altered expression with 500 mM salt (NaCl) vs 100 mM salt when food was present	DESeq(version 1.10.1), FDR < 0.05.	WBPaper00050726:OsmoticStress_regulated_Food
	Transcripts that showed significantly increased expression after animals were treated with 100uM Rapamycin and 50mM Metformin from day 1 to day 3 adult hermaphradite.	DESeq2(v1.14.1), fold change > 2, p-value < 0.05	WBPaper00055354:Rapamycin-Metformin_upregulated
	Transcripts expressed in body muscle, according to PAT-Seq analysis using Pmyo-3-GFP-3XFLAG mRNA tagging.	Cufflinks FPKM value >=1.	WBPaper00050990:body-muscle_expressed
	Transcripts expressed in GABAergic neuron, according to PAT-Seq analysis using Punc-47-GFP-3XFLAG mRNA tagging.	Cufflinks FPKM value >=1.	WBPaper00050990:GABAergic-neuron_expressed
	Transcripts expressed in hypodermis, according to PAT-Seq analysis using Pdpy-7-GFP-3XFLAG mRNA tagging.	Cufflinks FPKM value >=1.	WBPaper00050990:hypodermis_expressed
	Transcripts expressed in intestine, according to PAT-Seq analysis using Pges-1-GFP-3XFLAG mRNA tagging.	Cufflinks FPKM value >=1.	WBPaper00050990:intestine_expressed
	Maternal class (M): genes that are called present in at least one of the three PC6 replicates.	A modified Welch F statistic was used for ANOVA. For each gene, regressed error estimates were substituted for observed error estimates. The substitution is justified by the lack of consistency among the most and least variable genes at each time point. Regressed error estimates were abundance-dependent pooled error estimates that represented a median error estimate from a window of genes of similar abundance to the gene of interest. A randomization test was used to compute the probability Pg of the observed F statistic for gene g under the null hypothesis that developmental time had no effect on expression. P-values were not corrected for multiple testing.	[cgc5767]:expression_class_M
	Transcripts expressed in NMDA neuron, according to PAT-Seq analysis using Pnmr-1-GFP-3XFLAG mRNA tagging.	Cufflinks FPKM value >=1.	WBPaper00050990:NMDA-neuron_expressed
	Transcripts that showed significantly increased expression in day 1 adult hermaphrodite comparing to in L4 larva daf-16(mu86);glp-1(e2141) animals.	Fold change > 2, FDR < 0.05	WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
	Transcripts that showed significantly increased expression in day 1 adult hermaphrodite comparing to in L4 larva glp-1(e2141) animals.	Fold change > 2, FDR < 0.05	WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
Bacteria diet: Escherichia coli HB101. Fed for 30 generations.	Transcripts that showed significantly decreased expression after fed by bacteria E. coli HB101 for 30 generations comparing to animals fed by E. coli OP50.	DESeq2 fold change > 2, p-value < 0.01.	WBPaper00061007:HB101_downregulated
Bacteria diet: Sphingomonas aquatilis Yellow. Fed for 30 generations.	Transcripts that showed significantly decreased expression after fed by bacteria Sphingomonas aquatilis (Yellow) for 30 generations comparing to animals fed by E. coli OP50.	DESeq2 fold change > 2, p-value < 0.01.	WBPaper00061007:S.aquatilis_downregulated
Bacteria infection: Bacillus thuringiensis	mRNAs that showed significantly decreased expression after pathogenic bacteria Bacillus thuringiensis infections comparing to non pathogenic BT (BT247(1 to 10 mix) vs BT407 6h), according to RNAseq.	Cuffdiff, ajusted p-value < 0.01.	WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
Bacteria infection: Bacillus thuringiensis	mRNAs that showed significantly decreased expression after pathogenic bacteria Bacillus thuringiensis infections comparing to non pathogenic BT (BT247(1 to 10 mix) vs BT407 12h), according to RNAseq.	Cuffdiff, ajusted p-value < 0.01.	WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
Bacteria infection: Bacillus thuringiensis	mRNAs that showed significantly decreased expression after pathogenic bacteria Bacillus thuringiensis infections comparing to non pathogenic BT (BT247(1 to 2 mix) vs BT407 6h), according to RNAseq.	Cuffdiff, ajusted p-value < 0.01.	WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
Bacteria infection: Bacillus thuringiensis	mRNAs that showed significantly decreased expression after pathogenic bacteria Bacillus thuringiensis infections comparing to non pathogenic BT (BT247(1 to 2 mix) vs BT407 12h), according to RNAseq.	Cuffdiff, ajusted p-value < 0.01.	WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
	Transcripts that showed significantly increased expression in 10-days post L4 adult hermaphrodite N2 grown at 20C, comparing to in 1-day post L4 adult hermaphrodite N2 animals grown at 20C.	CuffDiff, fold change > 2.	WBPaper00065096:Day10_vs_Day1_upregulated
	Transcripts detected in body muscle nuclei according to a nuclear FACS-based strategy.	Cufflinks	WBPaper00065120:body-muscle-transcriptome
	Genes that showed expression levels higher than the corresponding reference sample (L2 all cell reference).	A Mann-Whitney U test with an empirical background model and FDR correction for multiple testing was used to detect expressed transcripts (Benjamini and Hochberg 1995). Genes and TARs with an FDR <= 0.05 were reported as expressed above background. Authors detected differentially expressed transcripts using a method based on linear models. Genes and TARs were called differentially expressed if the FDR was <= 0.05 and the fold change (FC) >= 2.0. To more strictly correct for potential false-positives resulting from multiple sample comparisons, authors divided individual FDR estimates by the number of samplesor sample comparisons, respectively. This resulted in an adjusted FDR of 1.3 * 0.0001 for expression above background and of 7.4 * 0.0001 for differential expression. Authors called genes selectively enriched in a given tissue if they met the following requirements: (1) enriched expression in a given tissue (FDR <= 0.05 and FC >= 2.0), (2) fold change versus reference among the upper 40% of the positive FC range observed for this gene across all tissues, and (3) fold-change entropy among the lower 40% of the distribution observed for all genes.	WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
	Transcripts that showed significantly decreased expression in tetraploid N2 comparing to diploid N2 animals at L4 larva stage.	DESeq2 R package (1.20.0), fold change > 2, and FDR < 0.05.	WBPaper00066110:tetraploid_vs_diploid_downregulated
	Genes that showed expression levels higher than the corresponding reference sample (L2 all cell reference).	A Mann-Whitney U test with an empirical background model and FDR correction for multiple testing was used to detect expressed transcripts (Benjamini and Hochberg 1995). Genes and TARs with an FDR <= 0.05 were reported as expressed above background. Authors detected differentially expressed transcripts using a method based on linear models. Genes and TARs were called differentially expressed if the FDR was <= 0.05 and the fold change (FC) >= 2.0. To more strictly correct for potential false-positives resulting from multiple sample comparisons, authors divided individual FDR estimates by the number of samplesor sample comparisons, respectively. This resulted in an adjusted FDR of 1.3 * 0.0001 for expression above background and of 7.4 * 0.0001 for differential expression. Authors called genes selectively enriched in a given tissue if they met the following requirements: (1) enriched expression in a given tissue (FDR <= 0.05 and FC >= 2.0), (2) fold change versus reference among the upper 40% of the positive FC range observed for this gene across all tissues, and (3) fold-change entropy among the lower 40% of the distribution observed for all genes.	WBPaper00037950:all-neurons_L2-larva_expressed
	Proteins that showed significantly decreased expression after 1-day-old wild type adults were exposed to cisplatin (300ug per mL) for 6 hours.	The differential expression analysis was performed in R. Differentially expressed proteins were identified by using a two-sided t-test on log-transformed data.	WBPaper00065373:Cisplatin_downregulated_WT
	Genes that showed expression levels higher than the corresponding reference sample (L3/L4 all cell reference).	A Mann-Whitney U test with an empirical background model and FDR correction for multiple testing was used to detect expressed transcripts (Benjamini and Hochberg 1995). Genes and TARs with an FDR <= 0.05 were reported as expressed above background. Authors detected differentially expressed transcripts using a method based on linear models. Genes and TARs were called differentially expressed if the FDR was <= 0.05 and the fold change (FC) >= 2.0. To more strictly correct for potential false-positives resulting from multiple sample comparisons, authors divided individual FDR estimates by the number of samplesor sample comparisons, respectively. This resulted in an adjusted FDR of 1.3 * 0.0001 for expression above background and of 7.4 * 0.0001 for differential expression. Authors called genes selectively enriched in a given tissue if they met the following requirements: (1) enriched expression in a given tissue (FDR <= 0.05 and FC >= 2.0), (2) fold change versus reference among the upper 40% of the positive FC range observed for this gene across all tissues, and (3) fold-change entropy among the lower 40% of the distribution observed for all genes.	WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed

21 Expression Patterns

• Primary Identifier: Expr2009712
• Pattern: Single cell embryonic expression. Only cell types with an expression fraction of greater 0.2 of the maximum expressed fraction are labeled (Full data can be downloaded from http://caltech.wormbase.org/pub/wormbase/datasets-published/packer2019/). The colors represent the broad cell class to which the cell type has been assigned. The size of the point is proportional to the log2 of the numbers of cells in the dataset of that cell type. Interactive visualizations are available as a web app (https://cello.shinyapps.io/celegans/) and can also be installed as an R package (https://github.com/qinzhu/VisCello.celegans).

• Primary Identifier: Expr1030188
• Pattern: Tiling arrays expression graphs

• Primary Identifier: Expr13556
• Pattern: cam-1 is broadly expressed in many cell types, including muscle, hypodermis, and neurons (Forrester et al. 1999), making direct identification of relevant cells difficult. To determine whether cam-1 is expressed in PVP and PVQ neurons, the Pcam-1::cam-1::GFP strain was crossed with hdIs26[Podr-2::CFP; Psra-6::dsRed2], which expresses CFP in PVP and dsRed in PVQ. Strong CAM-1 expression was observed in PVQ but only weak expression in PVP. CAM-1 is also expressed in PVT.

• Primary Identifier: Expr15120

• Primary Identifier: Expr1146
• Remark: Reporter gene fusion type not specified.
• Reporter Gene: [cam-1::gfp]. A functional cam-1gfp transgene that rescues the defects of cam-1 mutants.
• Pattern: CAM-1GFP expression appears at the 200-cell stage in most cells of the embryo. Migrating ALM, BDU, CAN, HSN and ccM cells, which migrate embryonically and require cam-1 function for their migration, are likely to express CAM-1GFP, as most cells of the embryo express the transgene while these cells migrate. During the first larval stage, V cells often express CAM-1GFP at the time that they divide, and the Q-neuroblast descendents, which also require cam-1 function for their migration, express CAM-1GFP. During larval development, CAM-1GFP is highly expressed in the nervous system, as well as in intestinal, hypodermal and body-wall muscle cells and in parts of the pharynx.
• Subcellular Localization: In non-neuronal cells, much of the protein appears to associate with the plasma membrane. In neurons, CAM-1GFP is detected predominantly in axons and dendrites.

• Primary Identifier: Expr2267
• Remark: Since these gfp fusions lack the introns and the 3' untranslated region, they might be lacking potential regulatory sequences. In that case, the gfp expression patterns may not precisely represent those of the endogenous kin-8 gene. cam-1 is called kin-8 in this article.
• Pattern: Expressed in chemosensory neurons in amphid: ASH. Other sensory neurons: ADE, FLP. Touch receptor neurons: AVM, ALM, PVM, PLM. Amphid interneurons: AIY, AIZ. Other interneurons: RIC, RMG, RIS, DVA, AVA, AVE, PVC, AVK, PVQ. Interneurons?: ALN, BDU, SDQ. Ring motor/inter neurons: RMD, RMDV. Ring motor neurons: RMED, RMEV Five neurons out of the following six, RIV, AVH, AVB, AVJ, AVD, AIN. About seven neurons in retrovesicular ganglion. Pharyngeal muscles in procorpus and isthmus. M4 and several pharyngeal neurons. A part of intestine and a few body wall muscles near the head (weak). Distal tip cells (sometimes and weak). A few ventral motor neurons and seam cells (rarely and weak). The expression patterns did not appear to change through the larva to adult stages. Embryonic expression was also observed.

• Primary Identifier: Expr2266
• Remark: Since these gfp fusions lack the introns and the 3' untranslated region, they might be lacking potential regulatory sequences. In that case, the gfp expression patterns may not precisely represent those of the endogenous kin-8 gene. cam-1 is called kin-8 in this article.
• Pattern: Expressed in chemosensory neurons in amphid: ADL, ASI, ASH, ASK. Sensory neuron: AUA. Interneurons: AIM, ADA, DVC, RIM, RIV, RMG, URX, AVE, PVT. About 10 neurons anterior to the nerve ring in the ring ganglion. About 2 neurons in the ventral ganglion. Four muscles in the head. The expression patterns did not appear to change through the larva to adult stages. Embryonic expression was also observed.

• Primary Identifier: Expr11631
• Pattern: Pcam-1b::GFP is expressed in all four RME cells.

• Primary Identifier: Expr11630
• Pattern: Pcam-1a::GFP is expressed in RMED and RMEV cells.

• Primary Identifier: Expr11657
• Pattern: Membrane-localized expression of CAM-1::GFP driven by the cam-1 promoter is seen in the ventral cord neurons and VPCs.

• Primary Identifier: Expr12070
• Pattern: Examination of endogenous cam-1 expression showed that cam-1 is expressed in the Q neuroblast lineage. Similar to mom-5, cam-1 was expressed at a significantly higher level in the QR descendants than in the QL descendants. Furthermore, the expression of cam-1 also gradually increases during QR lineage progression (average of 5.3 +/- 3.3 mRNA spots in QR, 5.5 +/- 4.8 mRNA spots in QR.p and 17 +/- 5.2 mRNA spots in QR.pa, n > 20).

• Primary Identifier: Expr1024436
• Pattern: Developmental gene expression time-course. Raw data can be downloaded from ftp://caltech.wormbase.org/pub/wormbase/datasets-published/levin2012

• Primary Identifier: Expr2027951
• Pattern: Single cell embryonic expression. Only cell types with an expression fraction of greater 0.2 of the maximum expressed fraction are labeled (Full data can be downloaded from http://caltech.wormbase.org/pub/wormbase/datasets-published/packer2019/). The colors represent the broad cell class to which the cell type has been assigned. The size of the point is proportional to the log2 of the numbers of cells in the dataset of that cell type. Interactive visualizations are available as a web app (https://cello.shinyapps.io/celegans/) and can also be installed as an R package (https://github.com/qinzhu/VisCello.celegans).

• Primary Identifier: Expr3509
• Subcellular Localization: CAM-1::YFP fluorescence could be detected in cholinergic motor neuron cell bodies and processes, typically outlining cell bodies in a manner consistent with localization to the cell membrane. In order to determine if CAM-1 expression in neuronal processes was associated with synapses, a transgenic strain was generated expressing both CAM-1::YFP and the synaptic vesicle marker SNB-1 fused to CFP. By using the acr-2 promoter to drive expression of SNB-1::CFP in cholinergic VA and VB motor neurons, CAM-1::YFP expression in cholinergic motor neurons was, in general, more diffuse than that of SNB-1::CFP. However, for regions in which punctate expression of CAM-1::YFP was detected, these puncta partially colocalized with SNB-1::CFP puncta. Interestingly, SNB-1::CFP puncta were identified that did not appear to be accompanied by an obvious area of increased CAM-1::YFP expression, suggesting that CAM-1 may be localized to a subset of cholinergic synapses. Occasionally, smaller CAM-1::YFP puncta that did not appear to be associated with obvious SNB-1::CFP puncta were also observed.

• Primary Identifier: Expr3574
• Subcellular Localization: Localized to only punctate structures in the DA motor neurons.

• Primary Identifier: Expr12902
• Subcellular Localization: GFP-tagged CAM-1 is localized to the proximal dendritic segment.

• Primary Identifier: Expr10002
• Subcellular Localization: LIN-17 and CAM-1 are expressed in muscle arms of transgenic worms and partially colocalized, suggesting that LIN-17 and CAM-1 might associate in muscle arms.

• Primary Identifier: Expr1143475
• Pattern: Developmental gene expression time-course. Raw data can be downloaded from ftp://caltech.wormbase.org/pub/wormbase/datasets-published/hashimshony2015

• Primary Identifier: Expr2268
• Remark: cam-1 is called kin-8 in this article.
• Subcellular Localization: Expression of a translational fusion construct for the type 2 KIN-8 protein, 33 C-terminal amino acid residues of which were replaced with GFP, was examined. The expression pattern was similar to Expr2267, but the KIN-8::GFP fusion protein was localized in the axons and plasma membranes.

• Primary Identifier: Expr12010
• Subcellular Localization: In cells that are sufficiently large so that subcellular localization is apparent, fluorescence appears to be associated with the periphery of cells in each strain, consistent with its expected membrane localization.

• Primary Identifier: Expr13943
• Subcellular Localization: CAM-1 was expressed in the postsynaptic region of the neuromuscular junction.

54 GO Annotation

8 Homologues

1 Locations

• Feature . Primary Identifier: WBGene00000289
• Start: 9295915
• End: 9310304
• Strand: -1

54 Ontology Annotations

0 Regulates Expr Cluster

1 Sequence

• Length: 14390

1 Sequence Ontology Term