WormMine: Gene WBGene00044802

• WormBase Gene ID: WBGene00044802
• Gene Name: ZC262.10
• Sequence Name: ZC262.10
• Organism: Caenorhabditis elegans
• Automated Description: Is affected by several genes including swsn-1; swsn-9; and etr-1 based on RNA-seq and microarray studies. Is affected by methylmercury hydroxide based on RNA-seq studies. Is predicted to encode a protein with the following domains: Tight junction protein, claudin-like and Tight junction protein, Claudin-like.
• Biotype: SO:0001217
• Genetic Position: :±
• Length (nt): 1128

1 Organism

• Name: Caenorhabditis elegans
• Taxon Id: 6239

1 Synonyms

• Value: WBGene00044802

Genomics

1 Transcripts

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
Transcript:ZC262.10.1	ZC262.10.1	528	III: 8345699-8346826

Other

1 CDSs

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:ZC262.10	ZC262.10	528	III: 8345699-8345963

0 RNAi Result

21 Allele

• gk964518
• gk963887
• WBVar02121414
• gk964133
• gk962890
• WBVar02121003
• WBVar02120685
• gk963858
• gk962809
• WBVar02121874
• WBVar02123059
• WBVar02124407
• WBVar02123384
• WBVar02121595
• WBVar02123228
• WBVar02123998
• WBVar02124959
• WBVar02122943
• f122
• gk963922
• WBVar02122819

1 Chromosome

• WormBase ID: III
• Organism: Caenorhabditis elegans
• Length (nt): 13783801

1 Chromosome Location

• Feature . Primary Identifier: WBGene00044802
• Start: 8345699
• End: 8346826
• Strand: -1

2 Data Sets

• WormBaseAcedbConverter
• C. elegans genomic annotations (GFF3 Gene)

1 Downstream Intergenic Region

• WormBase ID: intergenic_region_chrIII_8344337..8345698
• Length (nt): 1362
• Chromosome Location: III: 8344337-8345698
• Organism: Caenorhabditis elegans

26 Expression Clusters

Regulated By Treatment	Description	Algorithm	Primary Identifier
	Transcripts of coding genes that showed significantly decreased expression in muscle.	DESeq2 (version 1.24.0). Transcripts with a false-discovery rate adjusted p-value less than 0.05 were considered significantly differentially expressed.	WBPaper00062325:muscle_depleted_coding-RNA
	Transcripts that showed significantly increased expression in csr-1a(tor159) comparing to in N2 at 25C.	DESeq2, fold change > 2, p-value < 0.05.	WBPaper00061753:csr-1(tor159)_upregulated_25C
	Transcripts that showed significantly decreased expression in pals-22(jy3) comparing to in N2 animals.	limma-voom, fold change > 2, FDR < 0.05	WBPaper00064532:pals-22(jy3)_downregulated
	Transcripts that showed significantly decreased expression in bcf-1(ylf1) comparing to in N2 adult animals.	DESeq2	WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
Bacteria infection: N.ausubeli	Transcripts that showed significantly altered expression in C. elegans wild isolate strain JU1400 infected by N.ausubeli microsporidia spores for 72 hours at 21C starting from L1 larva stage.	FDR < 0.01	WBPaper00065086:JU1400_N.ausubeli_regulated
heat shock: 33C 30min	Transcripts that showed significantly decreased expression in hsf-1(RNAi) animals, after heat shock at 33 C for 30min, comparing to in hsf-1(RNAi) animals without heat shock.	Transcripts that were differentially expressed in different conditions, compared to the hsf-1(+);-HS control, were determined with CuffDiff, which uses the Benjamini-Hochberg correction for multiple testing to obtain the q-value (the FDR-adjusted the p-value).	WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi)
	Transcripts that showed significantly increased expression in swsn-1(os22ts) comparing to in N2 animals at young adult worms.	DESeq2, FDR<0.05 and fold-change 2. (Threshold set by WormBase curator.)	WBPaper00060764:swsn-1(os22ts)_upregulated
	Transcripts that showed significantly increased expression in nhl-2(ok818) comparing to in N2 at 25C.	EdgeR, FDR < 0.05, fold change < 0.5.	WBPaper00055971:nhl-2(ok818)_25C_downregulated
	Transcripts that showed significantly decreased expression in flcn-1(ok975) comparing to in N2.	Student's t-test.	WBPaper00056471:flcn-1(ok975)_downregulated
	Transcripts that showed significantly increased expression in pals-25(icb98) comparing to in N2 animals.	limma-voom, fold change > 2, FDR < 0.05	WBPaper00064532:pals-25(icb98)_upregulated
	Transcripts that showed significantly increased expression in sdc-3(ubs20) comparing to in control animals.	DESeq2 v.1.34, fold change > 2, FDR < 0.05.	WBPaper00067078:sdc-3(ubs20)_upregulated
	Genes that showed increased mRNA expression in emr-1(RNAi);lem-2(tm1582) comparing to N2.	Library siggenes in R was applied to select the differentially expressed loci using the false discovery rate-based SAM method. Genes presenting a delta value > 4 were considered to be significantly altered.	WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
	Transcripts that showed significantly decreased expression in him-17(me24) comparing to in N2 animals.	DESeq2, fold change > 2, FDR < 0.05.	WBPaper00064769:him-17(me24)_downregulated
	Transcripts that showed significantly increased expression in strain GC1459 containing daf-18(ok480) comparing to control strain GC1171.	edgeR, p-value < 0.05, fold change > 2.	WBPaper00061699:daf-18(ok480)_upregulated
	Transcripts that showed significantly increased expression in nhl-2(ok818) comparing to in N2 at 20C.	EdgeR, FDR < 0.05, fold change < 0.5.	WBPaper00055971:nhl-2(ok818)_20C_downregulated
	Transcripts that showed significantly decreased expression in Day 8 adults comparing to in Day 1 adults in neuron cells.	t-test, fold change > 2, p-value < 0.01.	WBPaper00062590:Aging_downregulated_neuron
Bacteria: C.neoformans strain H99	Transcripts that showed significantly increased expression after infection by C. neoformans H99.	Ballgown was used to calculate differential expression of genes using FPKM data and to generate tables with fold change and P values. Genes were shortlisted with a cutoff of 2-fold change and P values of less than 0.05.	WBPaper00059754:C.neoformans_H99_upregulated
	Transcripts that showed significantly decreased expression in nhr-8(hd117) comparing to in N2.	Differentially expressed genes were identified using Sleuth (version 0.30.0).	WBPaper00062446:nhr-8(hd117)_downregulated
Bacteria infection: N.ferruginous	Transcripts that showed significantly altered expression in C. elegans wild isolate strain JU1400 infected by N.ferruginous microsporidia spores for 72 hours at 21C starting from L1 larva stage.	FDR < 0.01	WBPaper00065086:JU1400_N.ferruginous_regulated
heat-killed OP50	Transcripts that showed significantly decreased expression in N2 L1 animals fed with heat-killed OP50 for 4 hours comparing to those animals fed with OP50.	DESeq2, fold change > 2, FDR < 0.05.	WBPaper00067214:Heat-Killed-OP50_downregulated
	Transcripts that showed significantly decreased expression in RA629 swsn-9(ok1354);rdIs49[Cb-unc-119] comparing to in RA577 swsn-9(ok1354); rdIs52 [Pric-19::swsn-9::gfp; Cb-unc-119] (swsn-9 neuronal rescue) animals at young adult worms.	DESeq2, FDR<0.05 and fold-change 2. (Threshold set by WormBase curator.)	WBPaper00060764:swsn-9(ok1354)_downregulated
	Genes with expression level down regulated after treatment with Methylmercury (MeHg) by RNAseq analysis.	Differential gene expression analysis was performed using Cuffdiff program of Cufflinks 1.3.0 for 44968 predicted transcripts. Transcripts with false discovery rate-corrected p-values (q-values) of < 0.05 and fold change > 2 (or < 0.5) were defined as differentially expressed.	WBPaper00043945:MeHg_downregulated
Fungi: Myzocytiopsis humicola extract	Transcripts that showed significantly decreased expression in old-1(ok1273) L4 larva animals after 4 hours of exposure to oomycete Myzocytiopsis humicola extract.	Differentially expressed genes as determined by Kallisto and Sleuth (pval < 0.01, qval < 0.1, fold change > 2).	WBPaper00065995:M.humicola-extract_downregulated_old-1(ok1273)
Bacteria infection: N.ferruginous	Transcripts that showed significantly altered expression in C. elegans wild isolate strain N2 infected by N.ferruginous microsporidia spores for 72 hours at 21C starting from L1 larva stage.	FDR < 0.01	WBPaper00065086:N2_N.ferruginous_regulated
	Transcripts that showed significantly decreased expression in dpy-26(ubs4) comparing to in control animals.	DESeq2 v.1.34, fold change > 2, FDR < 0.05.	WBPaper00067078:dpy-26(ubs4)_downregulated
	Transcripts that showed significantly increased expression in coh-1(ubs26) comparing to in control animals.	DESeq2 v.1.34, fold change > 2, FDR < 0.05.	WBPaper00067078:coh-1(ubs26)_downregulated

2 Expression Patterns

• Primary Identifier: Expr1162250
• Pattern: Developmental gene expression time-course. Raw data can be downloaded from ftp://caltech.wormbase.org/pub/wormbase/datasets-published/hashimshony2015

• Primary Identifier: Expr1020016
• Pattern: Developmental gene expression time-course. Raw data can be downloaded from ftp://caltech.wormbase.org/pub/wormbase/datasets-published/levin2012

0 GO Annotation

0 Homologues

1 Locations

• Feature . Primary Identifier: WBGene00044802
• Start: 8345699
• End: 8346826
• Strand: -1

0 Ontology Annotations

0 Regulates Expr Cluster

1 Sequence

• Length: 1128

1 Sequence Ontology Term