WormMine

WS295

Intermine data mining platform for C. elegans and related nematodes

Gene :

WormBase Gene ID  ? WBGene00206524 Gene Name  C54E10.11
Sequence Name  ? C54E10.11 Organism  Caenorhabditis elegans
Automated Description  Enriched in hypodermis; interfacial epithelial cell; vulC; and in male based on RNA-seq and single-cell RNA-seq studies. Is affected by several genes including csr-1; rrf-3; and hmg-3 based on microarray and RNA-seq studies. Is affected by multi-walled carbon nanotube; iron oxide nanoparticle; and stavudine based on RNA-seq and microarray studies. Biotype  SO:0001217
Genetic Position  Length (nt)  ? 790
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1 Organism

Name Taxon Id
Caenorhabditis elegans 6239

1 Synonyms

Value
WBGene00206524

Genomics

1 Transcripts

WormMine ID Sequence Name Length (nt) Chromosome Location
Transcript:C54E10.11.1 C54E10.11.1 244   V: 18801388-18802177
 

Other

1 CDSs

WormMine ID Sequence Name Length (nt) Chromosome Location
CDS:C54E10.11 C54E10.11 177   V: 18801433-18801591

0 RNAi Result

29 Allele

Public Name
gk963271
gk963489
gk963304
gk963809
gk963637
gk962724
tm10717
gk387023
gk836595
h5027
WBVar02076665
WBVar01992142
WBVar00224715
gk263215
gk263216
gk263218
gk263219
gk263217
WBVar01522419
WBVar01522420
WBVar01638669
WBVar00062131
WBVar00062121
WBVar00062126
WBVar00062116
WBVar01925304
WBVar01925303
WBVar01750388
WBVar01750389

1 Chromosome

WormBase ID Organism Length (nt)
V Caenorhabditis elegans 20924180  

1 Chromosome Location


Feature . Primary Identifier
Start End Strand
WBGene00206524 18801388 18802177 -1

2 Data Sets

Name URL
WormBaseAcedbConverter  
C. elegans genomic annotations (GFF3 Gene)  

1 Downstream Intergenic Region

WormBase ID Name Sequence Name Length (nt) Chromosome Location Organism
intergenic_region_chrV_18800827..18801387   561 V: 18800827-18801387 Caenorhabditis elegans

21 Expression Clusters

Regulated By Treatment Description Algorithm Primary Identifier
  Transcripts that showed significantly increased expression in ogt-1(ok1474) neuronal cells isolated by FACs comparing to in FACs isolated neuronal cells from wild type. DESeq2, fold change > 2, FDR < 0.05. WBPaper00066485:ogt-1(ok1474)_upregulated_neuron
  Transcripts that showed significantly altered expression after 24 hour exposure to stavudine (d4T) starting at L1 lava stage. DESeq WBPaper00053302:stavudine_24h_regulated
  Transcripts that showed significantly increased expression in 10-days post L4 adult hermaphrodite N2 grown at 20C, comparing to in 1-day post L4 adult hermaphrodite N2 animals grown at 20C. CuffDiff, fold change > 2. WBPaper00065096:Day10_vs_Day1_upregulated
  Transcripts that showed significantly decreased expression in dissected female germline comparing to in dissected male germline. Log2 Fold change > 2 or <-1, p-value < 0.05. WBPaper00053599:female_vs_male_downregulated
  Transcripts that showed significantly increased expression in BAT525 [hmg-3 (tm2539) / dpy-5(e61) unc-13(e1091) I.] comparing to in N2 at 1-day post L4 adult hermaphrodite stage. DESeq 2, fold change > 4, adjusted p-value < 0.05. WBPaper00055013:hmg-3(bar24)_upregulated
  Transcripts that showed significantly increased expression in hda-2(ok1479) comparing to in N2 animals. DESeq2 (version 1.28.1), FDR < 0.01, fold change > 2. WBPaper00062159:hda-2(ok1479)_upregulated
  Transcripts that showed significantly decreased expression in set-2(tm1630) animals at embryo stage, comparing to in N2 animals. DESeq2 (v2.1.8.3) was used to determine DE genes and to generate principal component and scatter plots. DE genes with FDR < 0.05 were analysed using g:Profiler with Bonferroni correction. WBPaper00060014:set-2(tm1630)_downregulated
Bacteria: B.thuringiensis Transcripts in elt-2(RNAi) animals that were significantly differentially expressed at least for one time point and one pathogenic strain Bt247 and Bt679 compared to the non pathogenic strain Bt407. Cuffdiff WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
  Transcripts that showed significantly increased expression in nas-38(ok3407) comparing to in N2. A feature was classified upregulated if its FDR-corrected p-value was <= 0.05 and fold change was >= 2. Analogously, a gene was classified downregulated if its FDR-corrected p-value was <= 0.05 and fold change was <= -2. WBPaper00060703:nas-38(ok3407)_upregulated
  Transcripts that showed significantly decreased expression in csr-1a(tor159) comparing to in N2 at 25C. DESeq2, fold change > 2, p-value < 0.05. WBPaper00061753:csr-1(tor159)_downregulated_25C
  Transcripts that showed significantly increased expression in elli-1(sam-3) comparing to in N2 animals, accordingto tiling array analysis. Fold change > 1.2, q-value < 0.05. WBPaper00050743:elli-1(sam-3)_upregulated
  Transcripts enriched in male him-5(e1490 animals, comparing to in N2 hermaphrodite animals from L3 larva to young adult stages. DESeq FDR < 0.01. WBPaper00050231:male_enriched
  Transcripts that showed significantly decreased expression in csr-1a(tor159) comparing to in N2 at 20C. DESeq2, fold change > 2, p-value < 0.05. WBPaper00061753:csr-1(tor159)_downregulated_20C
heat-killed OP50 Transcripts that showed significantly increased expression in N2 L1 animals fed with heat-killed OP50 for 4 hours comparing to those animals fed with OP50. DESeq2, fold change > 2, FDR < 0.05. WBPaper00067214:Heat-Killed-OP50_upregulated
  Transcripts that showed significantly decreased expression in nfki-1(cer1) animals at L4 larva stage, comparing to in N2 animals. Differentially expressed genes between wild type and knockouts were explored using DESeq2 R package (v.1.20.0) considering a threshold of adjusted p value < 0.01. WBPaper00060445:nfki-1(cer1)_downregulated_L4
  Genes down regulated in nhr-114(RNAi) comparing to glp-1(q224ts). Differentially expressed genes had a fold change cutoff of 2.0 and an unpaired t test p value cutoff of 0.05 for WT+Trp versus WT and 0.01 for nhr-114 versus glp-1. WBPaper00042194:nhr-114(RNAi)_downregulated
  Genes that showed significantly increased expression after exposure to 1mg/L MWCNTs from L1 larva to young adult. Transcripts with false discovery rate-corrected p-values < 0.05 and fold change > 2 were defined as differentially expressed. WBPaper00049377:MWCNT_upregulated
  Transcripts that showed significantly increased expression in rrf-3(pk1426) comparing to in N2 at L4 larva stage. DESeq2v 1.18.1, fold change > 1.5, adjusted p-value < 0.01. WBPaper00056169:rrf-3(pk1426)_upregulated_L4
Bacteria diet: heat-killed E. coli. Transcripts that showed significantly increased expression in L1 animals exposed to heat-killed bacteria for 4 hours, comparing to animals exposed to no food. DESeq2, fold change > 2, FDR < 0.05. WBPaper00064403:Heat-killed-E.Coli_upregulated
  Single-cell RNA-Seq cell group 30_1 expressed in hypodermis. scVI 0.6.0 WBPaper00065841:30_1
  Most down-regulated genes after Cit-SPIONs exposure (p<0.01). Past 3.03 was used for all statistical analyses. Statistical significance between two groups was assessed by t tests. A gene is determined to be differentially expressed when p < 0.01 and only 75 genes were selected as differentially regulated for each expression cluster. WBPaper00051437:Cit-SPIONs_downregulated

2 Expression Patterns

Remark Reporter Gene Primary Identifier Pattern Subcellular Localization
    Expr2001918 Single cell embryonic expression. Only cell types with an expression fraction of greater 0.2 of the maximum expressed fraction are labeled (Full data can be downloaded from http://caltech.wormbase.org/pub/wormbase/datasets-published/packer2019/). The colors represent the broad cell class to which the cell type has been assigned. The size of the point is proportional to the log2 of the numbers of cells in the dataset of that cell type. Interactive visualizations are available as a web app (https://cello.shinyapps.io/celegans/) and can also be installed as an R package (https://github.com/qinzhu/VisCello.celegans).  
    Expr1147122 Developmental gene expression time-course. Raw data can be downloaded from ftp://caltech.wormbase.org/pub/wormbase/datasets-published/hashimshony2015  

0 GO Annotation

0 Homologues

1 Locations


Feature . Primary Identifier
Start End Strand
WBGene00206524 18801388 18802177 -1

0 Ontology Annotations

0 Regulates Expr Cluster

1 Sequence

Length
790

1 Sequence Ontology Term