WormMine

WS297

Intermine data mining platform for C. elegans and related nematodes

GO Term : GO:0005656 nuclear pre-replicative complex GO

Namespace  cellular_component Obsolete  false
Description  A protein-DNA complex assembled at eukaryotic DNA replication origins during late mitosis and G1, allowing the origin to become competent, or 'licensed', for replication. The complex normally includes the origin recognition complex (ORC), Cdc6, Cdt1 and the MiniChromosome Maintenance (Mcm2-7) proteins.

0 Cross References

1 Data Sets

Name URL
GO Annotation data set  

1 Ontology

Name
GO

1 Ontology Annotations

Annotation Extension Qualifier
  part_of

21 Parents

Identifier Name Description
GO:0032991 protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
GO:0005575 cellular_component A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex).
GO:0005622 intracellular anatomical structure A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm.
GO:0110165 cellular anatomical structure A part of a cellular organism consisting of a material entity with granularity above the level of a protein complex but below that of an anatomical system. Note that cellular organisms exclude viruses.
GO:0140513 nuclear protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus.
GO:0043227 membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
GO:0043226 organelle Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.
GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
GO:0043229 intracellular organelle Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
GO:0043231 intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
GO:0005654 nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
GO:0031974 membrane-enclosed lumen The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen.
GO:0031981 nuclear lumen The volume enclosed by the nuclear inner membrane.
GO:0070013 intracellular organelle lumen An organelle lumen that is part of an intracellular organelle.
GO:0043233 organelle lumen The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.
GO:0032993 protein-DNA complex A macromolecular complex containing both protein and DNA molecules.
GO:0000808 origin recognition complex A multisubunit complex that is located at the replication origins of a chromosome.
GO:0097373 MCM core complex A protein complex that contains Mcm4, Mcm6, and Mcm7 proteins, and possesses DNA helicase activity. In the heterohexameric MCM complex, the Mcm4/6/7 proteins form a stable core, and Mcm2, Mcm3, and Mcm5 are more peripherally associated.
GO:0005656 nuclear pre-replicative complex A protein-DNA complex assembled at eukaryotic DNA replication origins during late mitosis and G1, allowing the origin to become competent, or 'licensed', for replication. The complex normally includes the origin recognition complex (ORC), Cdc6, Cdt1 and the MiniChromosome Maintenance (Mcm2-7) proteins.
GO:0036387 pre-replicative complex A protein-DNA complex that forms at the origin of replication during the initial step of DNA replication and allows the origin to become competent, or 'licensed', for replication.
GO:0042555 MCM complex A hexameric protein complex required for the initiation and regulation of DNA replication.

27 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
has part GO:0005656 GO:0000811
has part GO:0042555 GO:0005656
has part GO:0000808 GO:0005656
is_a GO:0036387 GO:0005656
is_a GO:0140513 GO:0005656
part of GO:0005654 GO:0005656
part of GO:0110165 GO:0005656
part of GO:0031974 GO:0005656
part of GO:0005622 GO:0005656
part of GO:0005634 GO:0005656
part of GO:0070013 GO:0005656
part of GO:0031981 GO:0005656
is_a GO:0005575 GO:0005656
has part GO:0097373 GO:0005656
has part GO:0005575 GO:0005656
part of GO:0043233 GO:0005656
is_a GO:0032991 GO:0005656
part of GO:0043231 GO:0005656
has part GO:0032991 GO:0005656
is_a GO:0032993 GO:0005656
part of GO:0043229 GO:0005656
part of GO:0043227 GO:0005656
part of GO:0005575 GO:0005656
part of GO:0043226 GO:0005656
has part GO:0005656 GO:0031261
has part GO:0005656 GO:0043596
has part GO:0005656 GO:0071162

3 Synonyms

Name Type
eukaryotic pre-replicative complex synonym
pre-replicative complex synonym
pre-RC synonym