|
WBPhenotype:0000124
|
enzyme activity reduced
|
Any variation that results in a decrease in the catalytic activity of an enzyme compared to control. Catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein (can include an RNA component). |
|
WBPhenotype:0000125
|
enzyme activity increased
|
Any variation that results in an increase in the catalytic activity of an enzyme compared to control. Catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein (can include an RNA component). |
|
WBPhenotype:0000733
|
catalysis variant
|
Any variation in the catalysis of a biochemical reaction compared to control. Catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein (can include an RNA component). |
|
WBPhenotype:0000726
|
ligand binding variant
|
Any variation of the specific binding of a molecule to its partner, which typically results in a change in cell activity, compared to control. |
|
WBPhenotype:0000193
|
dominant negative enzyme
|
Any variation within an enzyme that causes it to act antagonistically towards the wild-type enzymatic product. These mutations usually result in an altered molecular function (often inactive) and are characterized by a dominant or semi-dominant phenotype. |
