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GO:0003674
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molecular_function
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A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. |
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GO:0003824
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catalytic activity
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Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. |
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GO:0140640
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catalytic activity, acting on a nucleic acid
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Catalytic activity that acts to modify a nucleic acid. |
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GO:0140097
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catalytic activity, acting on DNA
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Catalytic activity that acts to modify DNA. |
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GO:0005488
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binding
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The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. |
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GO:0140657
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ATP-dependent activity
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A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient. |
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GO:0016853
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isomerase activity
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Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. |
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GO:0120543
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macromolecular conformation isomerase activity
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Catalysis of a reaction that alters the macromolecular conformation of a molecule. |
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GO:0005515
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protein binding
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Binding to a protein. |
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GO:0098772
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molecular function regulator activity
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A molecular function regulator regulates the activity of its target via non-covalent binding that does not result in covalent modification to the target. Examples of molecular function regulators include regulatory subunits of multimeric enzymes and channels. Mechanisms of regulation include allosteric changes in the target and competitive inhibition. |
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GO:0060590
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ATPase regulator activity
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Binds to and modulates the activity of an ATP hydrolysis activity. |
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GO:0030234
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enzyme regulator activity
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Binds to and modulates the activity of an enzyme. |
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GO:0004857
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enzyme inhibitor activity
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Binds to and stops, prevents or reduces the activity of an enzyme. |
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GO:0140678
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molecular function inhibitor activity
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A molecular function regulator that inhibits or decreases the activity of its target via non-covalent binding that does not result in covalent modification to the target. |
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GO:0008094
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ATP-dependent activity, acting on DNA
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Catalytic activity that acts to modify DNA, driven by ATP hydrolysis. |
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GO:0120545
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nucleic acid conformation isomerase activity
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Catalysis of a reaction that alters the conformation of a nucleic acid. |
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GO:0003916
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DNA topoisomerase activity
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Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA. |
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GO:0003918
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DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
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Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined, driven by ATP hydrolysis. The enzyme changes the linking number in multiples of 2. |
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GO:0072586
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DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) regulator activity
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Binds to and modulates the activity of ATP-hydrolyzing DNA topoisomerase. DNA topoisomerase (ATP-hydrolyzing) regulator activity catalyzes a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. |
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GO:0008657
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DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity
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Binds to and stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. |
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GO:0042030
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ATPase inhibitor activity
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Binds to and stops, prevents or reduces an ATP hydrolysis activity. |
