WormMine: GOTerm GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity GO

• Namespace: molecular_function
• Obsolete: false
• Description: Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined, driven by ATP hydrolysis. The enzyme changes the linking number in multiples of 2.

0 Cross References

1 Data Sets

• GO Annotation data set

1 Ontology

• Name: GO

43 Ontology Annotations

20 Parents

Identifier	Name	Description
GO:0003674	molecular_function	A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs.
GO:0003824	catalytic activity	Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0140640	catalytic activity, acting on a nucleic acid	Catalytic activity that acts to modify a nucleic acid.
GO:0140097	catalytic activity, acting on DNA	Catalytic activity that acts to modify DNA.
GO:0016787	hydrolase activity	Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
GO:0005488	binding	The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
GO:0016817	hydrolase activity, acting on acid anhydrides	Catalysis of the hydrolysis of any acid anhydride.
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	Catalysis of the hydrolysis of any acid anhydride which contains phosphorus.
GO:0016462	pyrophosphatase activity	Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups.
GO:0017111	ribonucleoside triphosphate phosphatase activity	Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate.
GO:0016887	ATP hydrolysis activity	Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
GO:0140657	ATP-dependent activity	A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient.
GO:0003676	nucleic acid binding	Binding to a nucleic acid.
GO:0016853	isomerase activity	Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.
GO:0120543	macromolecular conformation isomerase activity	Catalysis of a reaction that alters the macromolecular conformation of a molecule.
GO:0003677	DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
GO:0008094	ATP-dependent activity, acting on DNA	Catalytic activity that acts to modify DNA, driven by ATP hydrolysis.
GO:0120545	nucleic acid conformation isomerase activity	Catalysis of a reaction that alters the conformation of a nucleic acid.
GO:0003916	DNA topoisomerase activity	Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA.
GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined, driven by ATP hydrolysis. The enzyme changes the linking number in multiples of 2.

29 Relations

Relationship	Parent Term . Identifier	Child Term . Identifier
is_a	GO:0003916	GO:0003918
is_a	GO:0008094	GO:0003918
has part	GO:0003677	GO:0003918
is_a	GO:0140657	GO:0003918
is_a	GO:0003674	GO:0003918
has part	GO:0003674	GO:0003918
has part	GO:0005488	GO:0003918
has part	GO:0003676	GO:0003918
has part	GO:0017111	GO:0003918
has part	GO:0016462	GO:0003918
is_a	GO:0120545	GO:0003918
has part	GO:0003824	GO:0003918
is_a	GO:0016853	GO:0003918
is_a	GO:0120543	GO:0003918
has part	GO:0016787	GO:0003918
has part	GO:0016887	GO:0003918
is_a	GO:0140640	GO:0003918
is_a	GO:0003824	GO:0003918
is_a	GO:0140097	GO:0003918
has part	GO:0016817	GO:0003918
has part	GO:0016818	GO:0003918
negatively regulates	GO:0003918	GO:0008657
regulates	GO:0003918	GO:0008657
is_a	GO:0003918	GO:0034335
regulates	GO:0003918	GO:0072586
positively regulates	GO:0003918	GO:0072587
regulates	GO:0003918	GO:0072587
positively regulates	GO:0003918	GO:2000373
positively regulates	GO:0003918	GO:2000373

11 Synonyms

• Name: deoxyribonucleate topoisomerase
• Type: synonym

• Name: topoisomerase
• Type: synonym

• Name: DNA topoisomerase (ATP-hydrolysing)
• Type: synonym

• Name: DNA topoisomerase II
• Type: synonym

• Name: deoxyribonucleic topoisomerase activity
• Type: synonym

• Name: DNA topoisomerase type II activity
• Type: synonym

• Name: topoisomerase II
• Type: synonym

• Name: DNA topoisomerase II activity
• Type: synonym

• Name: DNA topoisomerase IV activity
• Type: synonym

• Name: type II DNA topoisomerase activity
• Type: synonym

• Name: GO:0061505
• Type: alt_id