WormMine

WS297

Intermine data mining platform for C. elegans and related nematodes

GO Term : GO:0030353 fibroblast growth factor receptor antagonist activity GO

Namespace  molecular_function Obsolete  false
Description  Interacts with the fibroblast growth factor receptor to reduce the action of another ligand, the agonist.

0 Cross References

0 Data Sets

1 Ontology

Name
GO

0 Ontology Annotations

32 Parents

Identifier Name Description
GO:0008150 biological_process A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence.
GO:0003674 molecular_function A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs.
GO:0065007 biological regulation Any process that modulates a measurable attribute of any biological process, quality or function.
GO:0050794 regulation of cellular process Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0050789 regulation of biological process Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
GO:0005488 binding The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
GO:0048519 negative regulation of biological process Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
GO:0048523 negative regulation of cellular process Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0005515 protein binding Binding to a protein.
GO:0098772 molecular function regulator activity A molecular function regulator regulates the activity of its target via non-covalent binding that does not result in covalent modification to the target. Examples of molecular function regulators include regulatory subunits of multimeric enzymes and channels. Mechanisms of regulation include allosteric changes in the target and competitive inhibition.
GO:0060089 molecular transducer activity A compound molecular function in which an effector function is controlled by one or more regulatory components.
GO:0048583 regulation of response to stimulus Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
GO:0010646 regulation of cell communication Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
GO:0009966 regulation of signal transduction Any process that modulates the frequency, rate or extent of signal transduction.
GO:0023051 regulation of signaling Any process that modulates the frequency, rate or extent of a signaling process.
GO:0048585 negative regulation of response to stimulus Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
GO:0009968 negative regulation of signal transduction Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction.
GO:0023057 negative regulation of signaling Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process.
GO:0010648 negative regulation of cell communication Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
GO:0005102 signaling receptor binding Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
GO:0038023 signaling receptor activity Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
GO:0030545 signaling receptor regulator activity Binds to and modulates the activity of a receptor.
GO:0140678 molecular function inhibitor activity A molecular function regulator that inhibits or decreases the activity of its target via non-covalent binding that does not result in covalent modification to the target.
GO:0070851 growth factor receptor binding Binding to a growth factor receptor.
GO:0005104 fibroblast growth factor receptor binding Binding to a fibroblast growth factor receptor (FGFR).
GO:0048019 receptor antagonist activity The activity of a gene product that interacts with a receptor to decrease the ability of the receptor agonist to bind and activate the receptor.
GO:0030547 signaling receptor inhibitor activity Binds to and modulates the activity of a signaling receptor.
GO:0090287 regulation of cellular response to growth factor stimulus Any process that modulates the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus.
GO:0030353 fibroblast growth factor receptor antagonist activity Interacts with the fibroblast growth factor receptor to reduce the action of another ligand, the agonist.
GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity.

38 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0005104 GO:0030353
is_a GO:0048019 GO:0030353
part of GO:0040037 GO:0030353
negatively regulates GO:0060089 GO:0030353
part of GO:0048585 GO:0030353
part of GO:0048523 GO:0030353
regulates GO:0038023 GO:0030353
part of GO:0090287 GO:0030353
is_a GO:0005102 GO:0030353
part of GO:0090288 GO:0030353
is_a GO:0005488 GO:0030353
negatively regulates GO:0003674 GO:0030353
part of GO:0040036 GO:0030353
is_a GO:0030545 GO:0030353
is_a GO:0140678 GO:0030353
is_a GO:0030547 GO:0030353
is_a GO:0098772 GO:0030353
part of GO:0010646 GO:0030353
has part GO:0005488 GO:0030353
part of GO:0010648 GO:0030353
part of GO:0050789 GO:0030353
part of GO:0023051 GO:0030353
part of GO:0008150 GO:0030353
regulates GO:0060089 GO:0030353
part of GO:0050794 GO:0030353
part of GO:0023057 GO:0030353
part of GO:0009966 GO:0030353
part of GO:0048519 GO:0030353
part of GO:0009968 GO:0030353
regulates GO:0003674 GO:0030353

2 Synonyms

Name Type
FGFR antagonist activity synonym
FGF receptor antagonist activity synonym